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Skin sensitisation leading to radiation burn: case report A 55-year-old woman developed skin sensitisation leading to radiation burn during treatment with chlorpropamide and tetracycline. Eventually, she died of systemic inflammatory response syndrome [not all routes stated; dosages, indications and durations of treatments to reactions onsets not stated]. The woman was hospitalised in the Turkey with severe burns to a burn care unit on postburn day 3. She reported that the burn injury occurred while she was under the artificial UVA lights at solarium center for cosmetic purposes. Following the initial examination, second and third degree burns on the body (approximately 73% body surface area) were noted, except for the genital region, breasts, inframammary skin and the skin on the chest wall that was protected by the breast. She had multiple comorbid problems, including chronic obstructive pulmonary disease and diabetes mellitus [not all comorbidities specified]. She had been receiving chlorpropamide and oral tetracycline which sensitizes skin to the damaging effects of UV-A lights. The woman was immediately taken to a cleaning tank following central and arterial catheterisation. She was irrigated by 37°C heated and sterilised water for 2 hours. Her body temperature was monitored to avoid hypothermia. Her blood gas analysis and metabolic status were in critical limits. The clinical and laboratory signs of presepsis were determined and noted. She required immediate intubation and ventilatory support due to respiratory distress signs. She was shifted to the intensive burn care unit. In subsequent days, she developed sepsis. She had fever and elevated WBC counts. Pseudomonas aeruginosa was cultured from the wounds and blood on post-burn day 14. She received unspecified antibiotic therapy and her burn areas were dressed with silver-coated antimicrobial barrier dressing with nanocrystalline silver every three day. However, she died of systemic inflammatory response syndrome on post-burn day 25. Author comment: "Patients who receive photosensitive drug and agents have to take care to avoid exposure to UV-A light." "She was using chlorpropamide and oral [tetracycline] which sensitizes skin to the damaging effects of UV-A lights." Sever C. Fatal burn due to solarium. Journal of Clinical and Analytical Medicine 2: 37-39, No. 1, Jan 2011. Available from: URL: http://doi.org/10.4328/JCAM.204 803442926 - Turkey

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