Cholecystokinin Antagonists in Gastroenterology Basic and Clinical S
A new presentation of physiological regulatory mechanisms and therapeutic applications is given in this book. It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and chara
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Cholecystokinin Antagonists in Gastroenterology Basic and Clinical Status Foreword by
Niklaus E. Gyr With 47 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Professor Dr. med., GUIDO ADLER Abteilung Innere Medizin I Medizinische Klinik und Poliklinik Oberer Eselsberg, Robert-Koch-StraBe 8 W-7900 Ulm, FRG Privatdozent Dr. med., CHRISTOPH BEGLINGER Abteilung fur Gastroenterologie Universitatsklinik, Peters graben 6 4031 Basel, Switzerland
ISBN-I3: 978-3-642-76364-9
e-ISBN-I3: 978-3-642-76362-5
001: 10.1007/978-3-642-76362-5 Library of Congress Cataloging-in-Publication Data. Cholecystokinin antagonists in gastroenterology: basic and clinical status/G. Adler, C. Beglinger (cds.); foreword by Niklaus E. Gyr. p. cm. Includes index. 1. Cholecystokinin - Antagonists - Therapeutic use - Testing. 2. Cholecystokinin - Physiologi3. Gastrointestinal system - Diseases - Chemotherapy. I. Adler, G. II. 8eglinger, C. (Christoph), 1950- . [DNLM: I. Cholecystokinin - antagonists & inhibitors. 2. Cholecystokinin - physiology. WK 170 C5469] RC802.C46 1991 616.3 - dc20 DNLMIDLC for Library of Congress 91-4841 CIP This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9, 1965, in its current version and a copyright fee must always be paid. Violations fall under the prosecution act of the German Copyright Law.
© Springer-Verlag Berlin Heidelberg
1991 Softcover reprint of the hardcover 1st edition 1991 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. Typesetting: Best-set Typesetter Ltd., Hong Kong 19/3130-543210 - Printed on acid-free paper
Foreword
Cholecystokinin (CCK) was the third peptide to be described among the large variety of gastrointestinal hormones known today. It was originally extracted from the intestinal mucosa and shown to exert distinct stimulatory effects on gallbladder contraction and on pancreatic enzyme secretion. At the time of its detection, the situation appeared simple and straightforward CCK and secretin were the hormonal regulators of pancreatic secretion and gallbladder contraction. A new hormonal concept replaced Pavlow's neuroregulatory scheme of exocrine pancreatic secretion. But things turned out to be much more complex. In fact, CCK has fooled bioche
