Cholesterol Modulation of Protein Function Sterol Specificity and In
In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such a
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Avia Rosenhouse-Dantsker Anna N. Bukiya Editors
Cholesterol Modulation of Protein Function Sterol Specificity and Indirect Mechanisms
Advances in Experimental Medicine and Biology Volume 1115
Editorial Board: IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Avia Rosenhouse-Dantsker • Anna N. Bukiya Editors
Cholesterol Modulation of Protein Function Sterol Specificity and Indirect Mechanisms
Editors Avia Rosenhouse-Dantsker Department of Chemistry University of Illinois Chicago, IL, USA
Anna N. Bukiya The University of Tennessee Health Science Center Memphis, TN, USA
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-3-030-04277-6 ISBN 978-3-030-04278-3 (eBook) https://doi.org/10.1007/978-3-030-04278-3 Library of Congress Control Number: 2018966812 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Cholesterol is one of the most talked-about molecules of modern times. This sterol was first obtained from gallstones in the mid-eighteenth century by French chemist François Poulletier de la Salle. His work was not published, but was referred to by his colleagues and collaborators. Another French chemist, Michel Eugène Chevreul, named the compound “cholesterine” in 1815, and this recognition opened an er
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