Choroidal thickening in retinal vein occlusion patients with serous retinal detachment
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Choroidal thickening in retinal vein occlusion patients with serous retinal detachment Lulu Chen 1,2 & Mingzhen Yuan 1,2 & Lu Sun 1,2 & Youxin Chen 1,2 Received: 16 June 2020 / Revised: 12 October 2020 / Accepted: 15 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To evaluate choroid thickness and macular retinal metrics in treatment naïve retinal vein occlusion (RVO) patients with serous retinal detachment (SRD) before and after intravitreal anti-vascular endothelial cell growth factor (VEGF) injection and to elucidate the possible role of choroid in the development of SRD and the potential role of SRD as a prognostic parameter. Methods This is a retrospective study involving 85 RVO patients, 41 central retinal vein occlusion (CRVO), and 44 branch retinal vein occlusion (BRVO), with macular edema: 21 central retinal vein occlusion and 22 branch retinal vein occlusion with SRD and the rest without SRD. Patients were evaluated with ophthalmic examinations and swept-source optical coherence tomography (SS-OCT) both before and 4–6 weeks after intravitreal anti-VEGF treatment. Choroid thickness and retinal metrics were measured and compared between SRD and non-SRD groups within each RVO subtype. Results In both CRVO and BRVO patients, the mean central subfield foveal thickness (CSFT) and central subfoveal choroid thickness (CSCT) of the SRD groups were thicker than those in the non-SRD groups (p < 0.05) at onset. After one anti-VEGF injection, CSFT and FNRT decreased in all groups (p < 0.05). The CSCTs were thicker in the SRD groups compared with the non-SRD groups (p < 0.05). The mean changes of CSFT were more remarkable in the SRD groups (p < 0.05). Conclusion Thicker choroid was a feature of naïve RVO patients with SRD and SRD may be an indicator of better anatomical recovery of retina in RVO patients after a single dose of anti-VEGF treatment.
Key messages Previous studies have shown that RVO patients tend to have thicker choroid layer, especially in those with serous retinal detachment. However, the possible role of choroid in the progress of RVO and the possible role of choroid in predicting treatment response was not well established. By analyzing choroid and macular metrics of RVO patients, including BRVO and CRVO patients, we found RVO patients with serous retinal detachment have thicker subfoveal choroid layer and have better anatomical response after single dose of anti-VEGF treatment.
Keywords Serous retinal detachment . Retinal vein occlusion
* Youxin Chen [email protected] 1
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
2
Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China
Introduction Macular edema secondary to retinal vein occlusion (RVO) is one of the most common causes of vision loss. Studies with optical coherence tomography (OCT) have discovered that macular edema secondary
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