Chromosome Translocation
This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which
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Yu Zhang Editor
Chromosome Translocation
Advances in Experimental Medicine and Biology Volume 1044 Editorial Board IRUN R. COHEN, The Weizmann Institute of Science, Rehovot, Israel ABEL LAJTHA, N.S. Kline Institute for Psychiatric Rrch, Orangeburg, NY, USA JOHN D. LAMBRIS, University of Pennsylvania, Philadelphia, PA, USA RODOLFO PAOLETTI, University of Milan, Milan, Italy NIMA REZAEI, Tehran University of Medical Sciences Children’s Medical Center, Children’s Medical Center Hospital, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Yu Zhang Editor
Chromosome Translocation
Editor Yu Zhang National Institute of Biological Sciences Beijing, China
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-13-0592-4 ISBN 978-981-13-0593-1 (eBook) https://doi.org/10.1007/978-981-13-0593-1 Library of Congress Control Number: 2018946723 © Springer Nature Singapore Pte Ltd. 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
1 Historical and Clinical Perspectives on Chromosomal Translocations................................................................................. 1 Ellen S. Wilch and Cynthia C. Morton 2 Induction of Chromosomal Translocations with CRISPR-Cas9 and Other Nucleases: Understanding the Repair Mechanisms That Give Rise to Translocations................................................... 15 Erika Brunet and Maria Jasin 3 Dynamics of Double-Strand Breaks: Implications for the Formation of Chromosome Translocations...................... 27 Henrike Johanna Gothe, Vera Minneker, and Vassilis Roukos 4 The CRISPR/Cas9
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