Chronic kidney disease in the context of multimorbidity patterns: the role of physical performance
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RESEARCH
Open Access
Chronic kidney disease in the context of multimorbidity patterns: the role of physical performance The screening for CKD among older people across Europe (SCOPE) study Andrea Corsonello1,2, Paolo Fabbietti2* , Francesc Formiga3, Rafael Moreno-Gonzalez3, Lisanne Tap4, Francesco Mattace-Raso4, Regina Roller-Wirnsberger5, Gerhard Wirnsberger5, Johan Ärnlöv6,7,8, Axel C. Carlsson6,8, Christian Weingart9, Ellen Freiberger10, Tomasz Kostka11, Agnieszka Guligowska11, Pedro Gil12, Sara Lainez Martinez12, Itshak Melzer13, Ilan Yehoshua14, Fabrizia Lattanzio1 and on behalf of SCOPE investigators
Abstract Background: Chronic kidney disease (CKD) is known to be associated with several co-occurring conditions. We aimed at exploring multimorbidity patterns associated with CKD, as well as the impact of physical performance and CKD severity on them in a population of older outpatients. Methods: Our series consisted of 2252 patients enrolled in the Screening of CKD among Older People across Europe multicenter observational study. Hypertension, stroke, transient ischemic attack, cancer, hip fracture, osteoporosis, Parkinson’s disease, asthma, chronic obstructive pulmonary disease, congestive heart failure, angina, myocardial infarction, atrial fibrillation, anemia, CKD (defined as GFR < 60, < 45 or < 30 ml/min/1.73 m2), cognitive impairment, depression, hearing impairment and vision impairment were included in the analyses. Physical performance was assessed by the Short Physical Performance Battery (SPPB) and used as stratification variable. Pairs of co-occurring diseases were analyzed by logistic regression. Patterns of multimorbidity were investigated by hierarchical cluster analysis. (Continued on next page)
* Correspondence: [email protected] 2 Laboratory of Geriatric Pharmacoepidemiology and Biostatistics, IRCCS INRCA, Via S. Margherita 5, 60124 Ancona, Italy Full list of author information is available at the end of the article
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