Chronic Obstructive Pulmonary Disease Co-Morbidities and Systemic Co
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality worldwide. By 2020, COPD is expected to be the fifth leading cause of disability and the third leading cause of death. COPD is associated with significant co-morbid i
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Linda Nici Richard ZuWallack ●
Editors
Chronic Obstructive Pulmonary Disease Co-Morbidities and Systemic Consequences
Editors Linda Nici, MD Clinical Professor of Medicine The Warren Alpert Medical School of Brown University Chief, Pulmonary and Critical Care, Providence Veterans Affairs Medical Center Providence, RI, USA [email protected]
Richard ZuWallack, MD Clinical Professor of Medicine University of Connecticut School of Medicine Associate Chief Pulmonary and Critical Care St. Francis Hospital and Medical Center Hartford, CT, USA [email protected]
ISBN 978-1-60761-672-6 e-ISBN 978-1-60761-673-3 DOI 10.1007/978-1-60761-673-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011935361 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
Chronic Obstructive Pulmonary Disease (COPD) is a preventable and treatable disease with commonly associated co-morbidities and significant systemic consequences. It is the fourth leading cause of death worldwide and the only one of the top ten leading causes of death that has shown a steady increase in morbidity and mortality. A major challenge in controlling and treating COPD is understanding its complexity. While COPD can be simplistically defined as a disease characterized by airflow limitation, we now understand it as a multicomponent disease with many clinical phenotypes. Evidence is rapidly emerging that COPD has a potent inflammatory basis which likely plays a role in the systemic consequences of the disease, including peripheral muscle, cardiac, nutritional, and psycho-social dysfunction. These systemic consequences are responsible for a large portion of the morbidity from this disease. Furthermore, patients with COPD are more likely to have significant co-morbid conditions, such a
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