Ciclosporin
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Ciclosporin Worsening of autophagic myopathy: case report
A 52-year-old man developed worsening of autophagic myopathy (AVM) during treatment with ciclosporin. The man presented with complaints of distal muscle weakness, persistent elevated creatine kinase (hyperCkaemia) and severe dilated cardiomyopathy. He also had family history of mild cardiomyopathy (one sister) and his mother had died of heart failure. A whole exome sequencing (WES) showed a novel heterozygous deletion in HSPB8 gene. Further investigations confirmed an impaired autophagy with AVM. Three months later, he received heart transplant and was started on immunosuppressive therapy with ciclosporin [route and dosage not stated]. At 1-year follow-up, a severe worsening of muscle weakness of axial and proximal districts was noted. A worsening of AVM due to ciclosporin was considered [outcome not stated]. Bruno G, et al. Deletion in HSPB8 gene leads to dilated cardiomyopathy with impaired autophagy worsened by immunosuppressive drugs: Characterization of a new phenotype. European Journal of Neurology 27 (Suppl. 1): 959 abstr. EPO2310, May 2020. Available from: URL: http://doi.org/10.1111/ene.14308 [abstract]
0114-9954/20/1819-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
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Reactions 29 Aug 2020 No. 1819
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