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Ciclosporin/nifedipine Gingival hyperplasia: case report

A 57-year-old man developed gingival hyperplasia during treatment with nifedipine for arterial hypertension and ciclosporin as immunosuppressive therapy [dosages and routes not stated]. The man had a medical history of polycystic kidney disease and arterial hypertension treated with nifedipine. He underwent aneurysmectomy of the anterior communicating artery in 1997. Thereafter, in 2001, he developed dilated cardiomyopathy and showed a reduced renal function, which was progressive. He was subjected to an extracorporeal dialysis in 2003, which resulted in the improvement of clinical and haemodynamic conditions. In 2004, he underwent left nephrectomy. Then, in 2007, a percutaneous transluminal coronary angioplasty and AVI stenting (coronary stent) followed with the placement of implantable cardioverterdefibrillator. He underwent kidney transplantation in 2010, which was associated with right nephrectomy. After the surgery, his urinary output immediately recovered. Subsequently, he was started on an immunosuppressive therapy including ciclosporin [cyclosporine], prednisone and mycophenolate. Since 2013, his kidney function was considerably stable. In September 2016, he was referred for a follow-up, where he exhibited severe gingival hyperplasia [duration of treatments to reaction onset not stated]. He reported inability to perform oral hygiene and increasing difficulty in eating. He felt miserable for his appearance. He had undergone several dental interventions frequently. The man’s therapy with nifedipine and ciclosporin was stopped, and he was switched to tacrolimus. He also underwent scalpel gingivectomy. Within a few months, his gingival overgrowth almost completely subsided. Esposito V, et al. Smile! (Life will be better). Journal of Nephrology 33: 653-655, No. 4, 2020. Available from: URL: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC7381466/

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Reactions 22 Aug 2020 No. 1818