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Renal tubular leak and prolonged myelosuppression: case report A 7-year-old girl developed a renal tubular leak and prolonged myelosuppression during treatment with cisplatin and doxorubicin for pancreatoblastoma. The girl presented to a medical centre with 3-weeks history of abdominal distension and pain. After various examinations, she was diagnosed with pancreatoblastoma, and a resection surgery was scheduled. Prior to the procedure, she started receiving preoperative chemotherapy with cisplatin and doxorubicin [exact dosages not stated; routes not stated]. A total of six courses of the preoperative chemotherapy were scheduled. After two cycles, examinations showed a significant reduction in the tumour volume. Based on the examinations, the tumour was deemed resectable with total or partial pancratectomy, but liver metastases was deemed unresectable. Hence, the chemotherapy was continued, and she was listed as priority in the United-Kingdom liver transplant registry. During the chemotherapy, she developed chemotherapy related a renal tubular leak and experienced prolonged myelosuppression [duration of treatments to reaction onsets not stated]. Therefore, the girl’s chemotherapy dose was modified [outcomes not stated]. She completed the scheduled six cycles of chemotherapy. Total cumulative dose of doxorubicin was 330 mg/m2 and that of cisplatin was 540 mg/m2. She received unspecified granulocyte-colony stimulating factors [G-CSF] concomitantly. One month after the last cycle of chemotherapy, she successfully underwent liver transplantation. During follow-up examination (4 years after liver transplantation), tests showed normal liver function with no disease recurrence. Mercadal-Hally M, et al. Pancreatoblastoma: A rare indication for liver transplantation in children. Hepatobiliary and Pancreatic Diseases International 19: 499-501, No. 5, Oct 2020. Available from: URL: http://doi.org/10.1016/j.hbpd.2020.07.003 803514187

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