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Hearing loss, cataract and oesophageal stenosis: 3 case report In a prospective study (IRB201703048) involving 17 patients who underwent treatment in between 2011 and 2017, three patients aged 7–11 years [sexes not stated] were described, who developed bilateral sensorineural hearing loss, unilateral cataract or oesophageal stenosis during treatment with cisplatin, paclitaxel or fluorouracil for nasopharyngeal carcinoma [routes and dosages not stated; not all durations of treatments to reactions onsets]. Case 1: A 7-year-old patient, who had nasopharyngeal carcinoma, received induction chemotherapy with cisplatin and fluorouracil [5-fluorouracil] followed by proton therapy. Additionally, the patient underwent radiotherapy with mean doses of 56.8Gy and 35.1Gy in ipsilateral and contralateral cochlea, respectively. Eleven months following the radiotherapy, the patient developed treatment-related side effect in the form of bilateral grade 3 sensorineural hearing loss requiring hearing aid. Case 2: An 11-year-old patient, who had nasopharyngeal carcinoma, received induction chemotherapy with cisplatin and fluorouracil [5-fluorouracil] followed by proton therapy. The patient’s primary tumour spread to ipsilateral lens requiring a mean radiotherapy dose of 49.6Gy. Subsequently, the patient developed treatment-related side effect in the form grade 3 unilateral cataract. Approximately 3 years following the radiotherapy, the patient underwent lens replacement procedure. Case 3: A 10-year-old patient, who had nasopharyngeal carcinoma, received induction chemotherapy with three cycles of cisplatin, fluorouracil [5-fluorouracil] and paclitaxel [taxol] followed by cisplatin and proton therapy. The maximum radiation dose of the oesophagus was 51.4Gy. Three months following the radiotherapy, the patient developed significant odynophagia and dysphagia. The patient was found to have developed treatment-related side effect in the form of oesophageal stenosis. Therefore, the patient received unspecified steroids to which the patient responded well. In addition, the patient was admitted and underwent endoscopic dilatation, which resulted in a complete resolution of swallowing function at an 83-month follow-up. Author comment: "Serious late toxicity included bilateral grade 3 hearing loss, unilateral cataract, and esophageal stenosis in one patient each." Uezono H, et al. Proton therapy following induction chemotherapy for pediatric and adolescent nasopharyngeal carcinoma. Pediatric Blood and Cancer 66: No. 12, Dec 2019. Available from: URL: http://doi.org/10.1002/pbc.27990 803441413 USA

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Reactions 21 Dec 2019 No. 1784