Classical Swine Fever and Related Viral Infections

The history of research on hog cholera (HC)/classical swine fever (CSF) can be roughly divided into three phases which are characterized by the methods available at the time for demonstrati ng the causati ve agent. Phase covered the period before the vira

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Yechiel Becker, Series Editor Julia Hadar, Managing Editor

DEVELOPMENTS IN VETERINARY VIROLOGY Payne, L.N. (ed.) Marek's Disease (1985) Burny, A. and Mammerickx, M. (eds.) Enzootic Bovine Leukosis and Bovine Leukemia Virus (1987) Becker, Y. (ed.) African Swine Fever (1987) De Boer, G.F. (ed.) Avian Leukosis (1987) Liess, B. (ed.) Classical Swine Fever and Related Viral Infections (1988)

DEVELOPMENTS IN MOLECULAR VIROLOGY Becker, Y. (ed.) Herpesvirus DNA (1981) Becker, Y. (ed.) Replication of Viral and Cellular Genomes (1983) Becker, Y. (ed.) Antiviral Drugs and Interferon: The Molecular Basis of Their Activity (1983) Kohn, A. and Fuchs, P. (eds.) Mechanisms of Viral Pathogenesis from Gene to Pathogen (1983) Becker, Y. (ed.) Recombinant DNA Research and Viruses. Cloning and Expression of Viral Genes (1985) Feitelson, M. Molecular Components of Hepatitis B Virus (1985) Becker, Y. (ed.) Viral Messenger RNA: Transcription, Processing, Splicing and Molecular Structure (1985) Doerfler, W. (ed.) Adenovirus DNA: The Viral Genome and Its Expression (1986) Aloni, Y. (ed.) Molecular Aspects of Papovaviruses (1987)

DEVELOPMENTS IN MEDICAL VIROLOGY Levine, P.H. (ed.) Epstein-Barr Virus and Associated Diseases (1985) Becker, Y. (ed.) Virus Infections and Diabetes Mellitus (1987)

CLASSICAL SWINE FEVER AND RELATED VIRAL INFECTIONS

edited by

B. Liess

Institut fur Virologie der Tierarztlichen Hochschule Hannover Hannover, Federal Republic of Germany

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Martinus Nijhoff Publishing

a member of the Kluwer Academic Publishers Group Boston/DordrechtiLancaster

Distributors for North America: Kluwer Academic Publishers 101 Philip Drive Assinippi Park Norwell, Massachusetts 02061, USA Distributors for the UK and Ireland: Kluwer Academic Publishers MTP Press Limited Falcon House, Queen Square Lancaster LAI IRN, UNITED KINGDOM Distributors for all other countries: Kluwer Academic Publishers Group Distribution Centre Post Office Box 322 3300 AH Dordrecht, THE NETHERLANDS

The figure on the cover is from Carbrey, A., "Diagnostic Procedures. " The figure appears on page 103 of this book.

Library of Congress Cataloging-in-Publication Data Classical swine fever and related viral infections. (Developments in veterinary virology) Includes bibliographies and index. I. Hog cholera. 2. Veterinary virology. I. Liess, B. II. Series. [DNLM: I. Hog Cholera. 2. Virus Diseasesveterinary. SF 973 C614) SF973.C48 1987 636.4'0896925 87-21979 ISBN-13: 978-1-4612-9235-7 e-ISBN-13: 978-1-4613-2083-8 DOl: 10.1007/978-1-4613-2083-8

Copyright © 1988 by Martinus Nijhoff Publishing, Boston Softcover reprint of the hardcover 1st edition 1988 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher, Martinus Nijhoff Publishing, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061.

CONTENTS

CONTRIBUTORS PREFACE

1. Description of the virus infection J