Clinical characteristics and outcomes in elderly with coronavirus disease 2019 in Beijing, China: a retrospective cohort
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Clinical characteristics and outcomes in elderly with coronavirus disease 2019 in Beijing, China: a retrospective cohort study Wei Zhang1 · Wei Hou1 · Ronghua Jin1 · Lianchun Liang1 · Bin Xu1 · Zhongjie Hu1 Received: 10 April 2020 / Accepted: 25 September 2020 © Società Italiana di Medicina Interna (SIMI) 2020
Abstract A novel human coronavirus, known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic of coronavirus disease 2019 (COVID-19). In this study, we aimed to explore the clinical characteristics and outcomes in older patients with COVID-19. Ninety-one patients with SARS-CoV-2 infection were included in the study, 27 of which (29.67%) were elderly. The median age of these 27 patients was 74.9 years (interquartile range 68–82; range 65–94 years), and 15 (55.56%) were female. Elderly with COVID-19 in Beijing (China) were more likely to have underlying comorbidities and more frequently tended to have critical illness and suffer from more complications. The main treatments of the elderly consisted of symptomatic and respiratory support. The most frequent complications in the elderly were pleural effusion [10, (37.04%)], secondary infection [7, (25.93%)], and kidney damage [7, (25.93%)]. Six (22.22%) of the 27 elderly patients received invasive ventilation (three of them switched to extracorporeal membrane oxygenation). As of March 7, 20 (74.07%) of the 27 elderly patients were discharged, two (7.41%) were still hospitalized, and five died; the mortality in the elderly was 18.52%. Age was associated with the mortality in patients with COVID-19 (OR 0.82; 95% CI 0.70–0.97; P = 0.019). Therefore, more attention should be paid to the treatment of comorbidities and complications in elderly patients. Keywords 2019 novel coronavirus disease (COVID-19) · Elderly · Clinical characteristics · Outcome
Introduction Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome (SARS)-like atypical pneumonia, which is a communicable disease that poses a serious public health threat [1, 2]. The pathogen was identified as severe acute * Zhongjie Hu [email protected] Wei Zhang [email protected] Wei Hou [email protected] Ronghua Jin [email protected]
respiratory syndrome coronavirus 2 (SARS-CoV-2) [3]. Although studies on the biological characteristics of SARSCoV-2 and clinical management of the disease have been conducted, our understanding of COVID-19 is still insufficient, especially concerning special populations, such as the elderly, pregnant women, and children. Preliminary data suggest that higher age is a risk factor for COVID-19 progression [4, 5]. However, the impact of aging on COVID-19 still remains largely unknown. Here, we retrospectively analyzed the clinical details of consecutive elderly patients with COVID-19 admitted to the Beijing YouAn Hospital. Our aim was to compare the characteristics, treatment options and outcomes between younger (
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