Clinical features of 47 secondary hemophagocytic lymphohistiocytosis patients complicated with capillary leak syndrome
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ORIGINAL ARTICLE
Clinical features of 47 secondary hemophagocytic lymphohistiocytosis patients complicated with capillary leak syndrome Changfeng Man1 · Mengmeng Wang1 · Guangli Yin1 · Jiayu Huang1 · Wanying Cheng1 · Xing Wu1 · Lingling Liu1 · Xin Gao2 · Jujuan Wang2 · Tian Tian2 · Limin Duan2 · Ji Xu2 · Hongxia Qiu1,2 Received: 24 April 2020 / Revised: 6 September 2020 / Accepted: 16 September 2020 © Japanese Society of Hematology 2020
Abstract The clinical features of patients with secondary hemophagocytic lymphohistiocytosis (sHLH) complicated with capillary leak syndrome (CLS) remain controversial. The data of 259 sHLH patients were retrospectively analyzed. The clinical manifestations, laboratory findings, treatment, and prognosis of the CLS-sHLH group and non-CLS-sHLH group were compared. The levels of fibrinogen, albumin, and serum calcium in the CLS-sHLH group were lower than in the non-CLS-sHLH group, and serum triglycerides in the CLS-sHLH group were higher than in the non-CLS-sHLH group (P 1.3 g/L (P
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