Clinical Outcome of IBD-Associated versus Sporadic Colorectal Cancer: A Matched-Pair Analysis
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ORIGINAL ARTICLE
Clinical Outcome of IBD-Associated versus Sporadic Colorectal Cancer: A Matched-Pair Analysis Bernhard W. Renz & Wolfgang E. Thasler & Gerhard Preissler & Tobias Heide & Philippe N. Khalil & Michael Mikhailov & Karl-Walter Jauch & Martin E. Kreis & Markus Rentsch & Axel Kleespies
Received: 21 June 2012 / Accepted: 8 February 2013 / Published online: 9 March 2013 # 2013 The Society for Surgery of the Alimentary Tract
Abstract Purpose This study assesses the perioperative course and long-term survival of inflammatory bowel disease (IBD)-associated vs. sporadic colorectal cancer (IBD-CRC vs. SCRC) after elimination of known confounders. Methods Between 1991 and 2007, n=3,299 patients underwent surgery for CRC at our institution. Thirty-three IBD patients were identified and compared to 165 SCRC using a matched-pair analysis (1:5 scenario). As matching parameters were used: age, gender, Union Internationale Contre le Cancer (UICC) stage, site of primary lesion, and date of surgery. After univariate analysis of the perioperative course, a multivariate survival analysis (Cox) of all patients (n=198) was performed. Results Significant differences were shown for preoperative symptoms (p=0.022), transfusion rate (p=0.01), ileostomy construction rate (p=0.001), total complication rate (p=0.042), and hospital stay (15 vs. 11 days, p
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