Clinical Pharmacology in Psychiatry Strategies in Psychotropic D
This book contains the papers from invited lecturers as well as selected contributions presented at the 6th International Meeting on Clinical Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva, Switzerland, 5-7 June 1991. At this meeting the basic the
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Clinical Pharmacology in Psychiatry Strategies in Psychotropic Drug Development
Edited by L.F. Gram L.P. Balant H.Y. Meltzer S.G. Dahl
With 29 Figures
Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest
Prof. Dr. LARS F. GRAM Dept. of Clinical Pharmacology, Odense University, Winsl0wparken 19, 5000 Odense C, Denmark Dr. Luc P. BALANT I.U.P.G., Unite de Recherche Clinique, 47, Rue du XXXI Decembre, 1207 Geneve, Switzerland Prof. HERBERT Y. MELTZER Department of Psychiatry, Case Western Res. Univ., 2040 Abington Road, Cleveland, Ohio 44106, U.S.A. Prof. SVEIN G. DAHL Institute of Medicinal Biology, University of Troms0, P.O. Box 977, 9037 Troms0, Norway
Vols. 1 and 2 of this series appeared under the title "Psychopharmacology Supplementum"
ISBN-13:978-3-642-78012-7 e-ISBN-13:978-3-642-78010-3 DOl: 10.1007/978-3-642-78010-3 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1993
Softcover reprint of the hardcover 1st edition 1993
The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Typesetting: Best-set Typesetter Ltd., Hong Kong 25/3130-5 4 3 2 1 0 - Printed on acid-free paper
Preface
This book contains the papers from invited lecturers as well as selected contributions presented at the 6th International Meeting on Clinical Pharmacology in Psychiatry (I.M.C.P.P.) held in Geneva, Switzerland, 5-7 June 1991. At this meeting the basic theme of the previous meetings in this series (Chicago 1979, Troms0 1980, Odense 1982, Bethesda 1985, Troms0 1988) was continued, namely, to bridge the gap between experimental development and clinical reality in psychopharmacology. After more than 25 years of intensive research in biological psychiatry, basic understanding of the biological mechanisms underlying major psychiatric diseases has advanced significantly but is still far from complete. Likewise, the hypotheses underlying the development of new psychotropics have been refined and produced a wide spectrum of novel, yet designed compounds. The crucial condition for all
