Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Kore
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RESEARCH ARTICLE
Open Access
Clinical profiles of subclinical disease among pulmonary tuberculosis patients: a prospective cohort study in South Korea Jinsoo Min1, Chaeuk Chung2, Sung Soo Jung2, Hye Kyeong Park3, Sung‑Soon Lee3 and Ki Man Lee4,5*
Abstract Background: Subclinical tuberculosis (TB) is a potential target for public health intervention because its early iden‑ tification may reduce TB transmission. We aimed to describe the clinical and laboratory findings of subclinical disease among pulmonary TB patients and compared treatment outcomes for subclinical and active diseases. Methods: In this prospective cohort study, we enrolled adult patients aged ≥ 19 years with pulmonary TB between 2016 and 2018. Subclinical TB was defined as radiographic or microbiologic test results consistent with TB without clinical symptoms. We implemented a two-stage symptom assessment using a predefined TB symptom checklist. Demographic, clinical, and laboratory data were compared between subclinical and active diseases using multivari‑ able binary logistic regression analysis. We evaluated treatment outcomes in the drug-susceptible cohort. Results: Among 420 enrolled patients, 81 (19.3%) had subclinical TB. Multivariable analysis showed that age
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