Clinical Significance of Diffuse 18 F-FDG Uptake in Residual Thyroid Gland after Unilateral Thyroid Lobectomy
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ORIGINAL ARTICLE
Clinical Significance of Diffuse 18F-FDG Uptake in Residual Thyroid Gland after Unilateral Thyroid Lobectomy Hee-Sung Song & Su Jin Lee & Seok-Ho Yoon & Jandee Lee & Euy-Young Soh & Young-Sil An & Joon-Kee Yoon
Received: 22 April 2011 / Accepted: 30 June 2011 / Published online: 26 July 2011 # Korean Society of Nuclear Medicine 2011
Abstract Purpose We investigated the clinical significance of diffuse uptake in remaining thyroid after unilateral lobectomy for thyroid cancer. Methods A total of 144 thyroid cancer patients who underwent 18F-FDG PET/CT after lobectomy were enrolled in the present study. The PET/CT images were evaluated for the presence of diffuse 18F-FDG uptake with maximum SUV (SUVmax) >2.0 in the residual thyroid and placed into one of two groups: with diffuse uptake and without diffuse uptake group. Clinical, laboratory, and PET/CT parameters in both groups were compared. Correlations between SUVmax of thyroid and available parameters were analyzed. Results Forty-two of 144 patients (29.2%) had diffuse thyroid uptake (mean SUVmax: 3.2±1.1). All patients with diffuse uptake and 96 (94.1%) without diffuse uptake were receiving thyroxine therapy (P=0.09). Thyroid function tests showed that most patients were euthyroid status (78.6 vs. 85.3%, P=0.36). TgAb levels were significantly higher in patients with diffuse uptake (338.0±664.6 vs. 57.3±46.4, P
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