Clinical significance of dysregulation of miR-381 in pediatric acute myeloid leukemia
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(2020) 25:42 Zhang et al. Eur J Med Res https://doi.org/10.1186/s40001-020-00442-1
Open Access
RESEARCH
Clinical significance of dysregulation of miR‑381 in pediatric acute myeloid leukemia Piqiang Zhang, Deyun Sun, Xuemei Sun and Hongjuan Li*
Abstract Background: microRNA-381 is dysregulated in a variety of cancers. However, its clinical significance in pediatric acute myeloid leukemia (AML) is still unclear. The purpose of this study was to detect the expression level of miR-381 in pediatric AML patients and to explore its potential clinical significance. Methods: The levels of miR-381 in bone marrow and serum of 102 pediatric AML patients were measured by quantitative real-time polymorperase chain reaction (qRT-PCR). The diagnostic value of serum miR-381 in pediatric AML patients was evaluated by the receiver operating characteristic (ROC) curve. A Chi square test was used to analyze the relationship between serum miR-381 and the clinical characteristics of patients. Cox regression analysis and Kaplan– Meier evaluated the prognostic value of serum miR-381 in patients. Finally, the proliferation of the cells was analyzed by the CCK-8 assay. Results: Compared with healthy controls, the levels of miR-381 in serum and bone marrow of pediatric AML patients were significantly decreased (P
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