Clinical significance of glycated hemoglobin in acute coronary syndrome patients from the CCC-ACS project
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Xin Zhao1 for CCC investigators · Yi Kang2 for CCC investigators · Xiaozeng Wang1 for CCC investigators · Xiaoxu Yang3 for CCC investigators · Guannan Ai1,4 for CCC investigators · Yifei Liu1,4 for CCC investigators · Pei Xu1,4 for CCC investigators · Jiyuan Zhang1,4 for CCC investigators · Chonghuai Gu5 for CCC investigators · Yan Zhang6 for CCC investigators · Yongchen Hao7 for CCC investigators · Dong Zhao7 for CCC investigators · Yaling Han1 for CCC investigators 1
Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China Department of Heart Center, First Hospital of Tsinghua University, Beijing, China 3 Department of Cardiology, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, China 4 Jinzhou Medical University, Jinzhou, China 5 Department of Cardiology, Anqing Hospital Affiliated to Anhui Medical University, Anqing, China 6 Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China 7 Department of Epidemiology, Beijing An zhen Hospital, Beijing, China 2
Clinical significance of glycated hemoglobin in acute coronary syndrome patients from the CCCACS project Findings from a multicenter retrospective observational study Electronic supplementary material The online version of this article (https://doi. org/10.1007/s00059-020-04999-9) contains supplementary material, which is available to authorized users.
non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA). Patients with ACS suffer a high risk of death, cardiogenic shock, recurrent myocardial infarction (MI), and heart failure, particularly in patients with acute
MI (AMI), the leading cause of morbidity and mortality worldwide [1]. Thus, it is important to determine the prognosis of ACS patients so as to promote interventions that might prevent adverse cardiovascular events.
Acute coronary syndrome (ACS) refers to a spectrum of conditions compatible with acute myocardial ischemia and/or due to an abrupt reduction in coronary blood flow. Acute coronary syndrome includes ST-elevation myocardial infarction (STEMI) and non-ST-elevation ACS (NSTE-ACS), which encompasses Xin Zhao and Yi Kang contributed equally to the manuscript. Availability of data and materials The datasets used and/or analyzed during the current study are available from the CCC-ACS project. Code availability The statistical analyses were used the IBM SPSS program (Version 23.0).
Fig. 1 8 Flowchart of patient enrollment. ACS acute coronary syndrome, HbA1c glycated hemoglobin Herz
Original articles Table 1 Baseline characteristics of patients Characteristics
Group I HbA1c < 5.7%
Group II HbA1c 5.7–6.4%
Group III HbA1c ≧ 6.5%
p
Age, years
60.01 ± 12.96
63.61 ± 12.09
62.60 ± 11.73
0.000
Male
6084 (81.1)
7403 (76.6)
7220 (71.0)
0.000
BMI, kg/m
2
23.98 ± 3.29
24.35 ± 3.50
24.94 ± 3.42
0.000
Heart rate, bpm
76.18 ± 15.28
77.14 ± 15.96
80.00 ± 16.48
0.000
SBP, mm Hg
129.31 ± 23.22
130.27 ± 23.55
133.06 ± 23.62
0.000
Hypertension
3541 (47.2)
5169
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