Clinical significance of glycated hemoglobin in acute coronary syndrome patients from the CCC-ACS project

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Xin Zhao1 for CCC investigators · Yi Kang2 for CCC investigators · Xiaozeng Wang1 for CCC investigators · Xiaoxu Yang3 for CCC investigators · Guannan Ai1,4 for CCC investigators · Yifei Liu1,4 for CCC investigators · Pei Xu1,4 for CCC investigators · Jiyuan Zhang1,4 for CCC investigators · Chonghuai Gu5 for CCC investigators · Yan Zhang6 for CCC investigators · Yongchen Hao7 for CCC investigators · Dong Zhao7 for CCC investigators · Yaling Han1 for CCC investigators 1

Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China Department of Heart Center, First Hospital of Tsinghua University, Beijing, China 3 Department of Cardiology, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, China 4 Jinzhou Medical University, Jinzhou, China 5 Department of Cardiology, Anqing Hospital Affiliated to Anhui Medical University, Anqing, China 6 Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China 7 Department of Epidemiology, Beijing An zhen Hospital, Beijing, China 2

Clinical significance of glycated hemoglobin in acute coronary syndrome patients from the CCCACS project Findings from a multicenter retrospective observational study Electronic supplementary material The online version of this article (https://doi. org/10.1007/s00059-020-04999-9) contains supplementary material, which is available to authorized users.

non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA). Patients with ACS suffer a high risk of death, cardiogenic shock, recurrent myocardial infarction (MI), and heart failure, particularly in patients with acute

MI (AMI), the leading cause of morbidity and mortality worldwide [1]. Thus, it is important to determine the prognosis of ACS patients so as to promote interventions that might prevent adverse cardiovascular events.

Acute coronary syndrome (ACS) refers to a spectrum of conditions compatible with acute myocardial ischemia and/or due to an abrupt reduction in coronary blood flow. Acute coronary syndrome includes ST-elevation myocardial infarction (STEMI) and non-ST-elevation ACS (NSTE-ACS), which encompasses Xin Zhao and Yi Kang contributed equally to the manuscript. Availability of data and materials The datasets used and/or analyzed during the current study are available from the CCC-ACS project. Code availability The statistical analyses were used the IBM SPSS program (Version 23.0).

Fig. 1 8 Flowchart of patient enrollment. ACS acute coronary syndrome, HbA1c glycated hemoglobin Herz

Original articles Table 1 Baseline characteristics of patients Characteristics

Group I HbA1c < 5.7%

Group II HbA1c 5.7–6.4%

Group III HbA1c ≧ 6.5%

p

Age, years

60.01 ± 12.96

63.61 ± 12.09

62.60 ± 11.73

0.000

Male

6084 (81.1)

7403 (76.6)

7220 (71.0)

0.000

BMI, kg/m

2

23.98 ± 3.29

24.35 ± 3.50

24.94 ± 3.42

0.000

Heart rate, bpm

76.18 ± 15.28

77.14 ± 15.96

80.00 ± 16.48

0.000

SBP, mm Hg

129.31 ± 23.22

130.27 ± 23.55

133.06 ± 23.62

0.000

Hypertension

3541 (47.2)

5169