Clinical value of histologic endometrial dating for personalized frozen-thawed embryo transfer in patients with repeated
- PDF / 2,370,966 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 41 Downloads / 175 Views
RESEARCH ARTICLE
Open Access
Clinical value of histologic endometrial dating for personalized frozen-thawed embryo transfer in patients with repeated implantation failure in natural cycles Yuan Li1,2,3, Xiao feng Li1,2, Jing nan Liao1,3, Xiang xiu Fan1,3, Yong bin Hu4, Runxin Gan2, Guangxiu Lu2,3, Ge Lin1,2,3 and Fei Gong1,2,3*
Abstract Background: Displacement of the window of implantation (WOI) has been proposed as an important factor contributing to repeated implantation failure (RIF). However, the use of histologic endometrial dating as a diagnostic tool of endometrial receptivity has been questioned. Methods: This study is a prospective intervention trial that enrolled 205 infertile patients from July 2017 to December 2017. Endometrial biopsies from 50 patients with good prognoses were conducted on day 3 (n = 6), 5 (n = 6), 7 (n = 26), 9 (n = 6), or 11 (n = 6) post-ovulation (PO + 3/5/7/9/11) of the previous natural cycle before their conventional frozen-thawed embryo transfer (FET) cycle. We conducted endometrial biopsies for 155 RIF patients on day PO + 7. Results: The verification of the Noyes criteria for endometrial dating was conducted at different times (PO + 3/+ 5/ + 7/+ 9/+ 11) on 41 patients with good prognoses who achieved an ongoing pregnancy in their first conventional FET cycle after endometrial biopsy. The agreement between two pathologists determining endometrial biopsy dating results in infertile patients was determined to be acceptable (weighted kappa = 0.672, P < 0.001). The rate of out-of-phase dating on day PO + 7 was significantly higher in RIF patients than in good- prognosis patients (31.6% vs. 3.8%, P = 0.003). pFET was performed in 47 RIF patients diagnosed to be out of phase, and the cumulative livebirth rate was 61.7%. Conclusions: Histologic endometrial dating of RIF patients in natural cycles may be a biomarker for a receptive endometrium in diagnosing WOI displacement. (Continued on next page)
* Correspondence: [email protected] 1 Institute of Reproduction and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China 2 Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a
Data Loading...
