Clinicopathologic analysis of gastric mucosa-associated lymphoid tissue lymphoma with or without c-Met expression
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ORIGINAL PAPER
Clinicopathologic analysis of gastric mucosa‑associated lymphoid tissue lymphoma with or without c‑Met expression Rika Omote1 · Yuka Gion1,2 · Shizuma Omote1 · Akira Tari3 · Takehiro Tanaka1 · Asami Nishikori2 · Tadashi Yoshino1 · Yasuharu Sato1,2 Received: 28 October 2019 / Accepted: 19 December 2019 © The Japanese Society for Clinical Molecular Morphology 2020
Abstract Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach is mainly associated with Helicobacter pylori infection, and H. pylori eradication therapy is often effective. However, 20–30% of the cases of MALT lymphoma are resistant to the eradication therapy, and translocation of the API2-MALT1 gene is often found in these cases. Most cases without translocation of API2-MALT1 are localized to the stomach, whereas some cases with this translocation are a more advanced stage of MALT lymphoma that spreads to other organs. The c-Met receptor is a prognostic factor involved in infiltration and metastasis in many malignant tumors, including gastric, pancreatic, lung, and kidney cancer. In the present study, the expression of c-Met in 43 cases of gastric MALT lymphomas was immunohistochemically examined and compared with clinicopathological factors. To elucidate the significance of c-Met in MALT lymphoma, the expression intensity of c-Met in 22 API2-MALT1 translocation-positive and 21 API2-MALT1 translocation-negative cases was scored, compared, and examined. The immunohistochemistry analysis revealed strong staining for c-Met in 21 API2MALT1 translocation-positive cases and in 1 translocation-negative case (P = 0.00). This result indicates the relationship between strong expression of c-Met and the progression of MALT lymphoma with API2-MALT1 gene translocation. Keywords Mucosa-associated lymphoid tissue lymphoma · Chromosomal translocation · Helicobacter pylori · Eradication · Stomach neoplasms · c-Met protein · HGF receptor
Introduction Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) lymphoma occurs in the extranodal organs such as the lungs, throat, thyroid gland, and gastrointestinal tract around the stomach [1]. Approximately 90–95% of the gastric MALT lymphomas are associated with Helicobacter pylori infection [2, 3]. Most patients with this * Yasuharu Sato satou‑y@okayama‑u.ac.jp 1
Department of Pathology, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Okayama, Japan
2
Division of Pathophysiology, Okayama University Graduate School of Health Sciences, 2‑5‑1 Shikata‑cho, Kita‑ku, Okayama 700‑8558, Japan
3
Division of Internal Medicine, Chugoku Central Hospital of the Mutual Aid Association of Public School, Hiroshima, Japan
infection can be cured with H. pylori eradication therapy, but some patients without the infection do not respond well to eradication therapy, and advanced stages of the lymphoma often occur [4]. Nevertheless, some patients with MALT lymphoma not associated with H. pylori infection have
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