Clinicopathologic characteristics and surgical outcome of synthetic fiber conjunctival granuloma
- PDF / 4,978,924 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 91 Downloads / 166 Views
RESEARCH ARTICLE
Open Access
Clinicopathologic characteristics and surgical outcome of synthetic fiber conjunctival granuloma Zhang Chen1, Tianyang Wang2, Qintuo Pan1, Zhaoliang Zhang1
and Zongduan Zhang1*
Abstract Background: Until recently, synthetic fiber conjunctival granuloma (SFCG) is rarely reported and has been poorly understood. Our study was to explore the clinical features, histopathologic characteristics, surgical outcomes, and prognosis of SFCG after surgical excision. Methods: Retrospective review of clinical findings, histopathological and immunohistochemical studies identified 18 cases of SFCG. Specimens were routinely processed and stained with H&E. Immunohistochemical stains for GMS, PAS, CD68 and CK-pan were also performed. Results: Eighteen patients with an average age of 9.3 ± 6.6 years had a tender white to red mass on the conjunctiva. All the lesions were completely removed, and none of the patients relapsed. Histologically, all of the specimens revealed inflammatory granulation tissues with a large number of inflammatory cells infiltration and the presence of synthetic fibers. Immunohistochemical stains were positive for CD68, CK, GMS and PAS. Conclusions: Synthetic fiber conjunctival granuloma is an uncommon lesion with foreign body sensation caused by inoculation of synthetic exogenous materials. These lesions are mostly unilateral and occur in the inferior conjunctival fornix. SFCGs are characterized by a large number of inflammatory cells infiltration and the presence of synthetic fibers. Surgical excision followed by topical corticosteroids has been clinically proven to be effective. Keywords: Synthetic fiber conjunctival granuloma, Clinical feature, Histopathologic
Background Many non-synthetic and synthetic exogenous materials may play a vital role in causing foreign body conjunctival granulomas. To date, several studies have indicated synthetic fiber as a possible cause of conjunctival granuloma in children [1–3]. It is sometimes called “teddy bear” granuloma because some cases were caused by the materials used to produce stuffed animals [4]. It is also a rare granulomatous foreign body reaction of the conjunctiva [5]. The eye’s protective mechanism of blinking and tearing * Correspondence: [email protected] 1 Wenzhou Medical University Eye Hospital, 270 Xueyuan Road, Wenzhou 325027, Zhejiang, China Full list of author information is available at the end of the article
usually removes foreign bodies from the ocular surface. However, a research has reported that children were more tolerant to ocular irritation caused by foreign bodies, and foreign bodies may occasionally embed in the underlying stroma and be encapsulated by the mucous [6]. Retaining these materials may initiate a local chronic inflammatory response that cause lesions [4]. Synthetic fiber conjunctival granuloma (SFCG) is relatively rare. It is usually unilateral and located in the inferior conjunctival fornix. The patients usually have no history of trauma and are asymptomatic [5]. All of the lesions in our case ser
Data Loading...
