• PDF / 169,646 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 106 Downloads / 166 Views

DOWNLOAD

REPORT

---

1

Cobicistat/darunavir/cobicistat/darunavir/emtricitabine/tenofovir-alafenamide/darunavir/ ritonavir

S

Various toxicities and off-label use: 9 case reports In a retrospective single-center observational study of 55 patients conducted between 15 March 2020 and 15 May 2020, 9 patients [7 men and 2 women] aged 39–76 years were described, who developed cutaneous rash, thrombocytosis, tonic-clonic seizures, QT-prolongation, diarrhoea or asthenia following treatment with cobicistat/darunavir/emtricitabine/tenofovir-alafenamide for HIV infection or following off-label use of cobicistat/darunavir or darunavir/ritonavir for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Out of 9 patients, eight patients had SARS-CoV2 infection and one patient had HIV infection. The patients, who had SARS-CoV2 infection, received off-label treatment with oral cobicistat/darunavir 150/800 mg/day (4 patients) and oral darunavir/ritonavir 800/100 mg/day (4 patients). The patient, who had HIV infection, received treatment with oral cobicistat/darunavir/emtricitabine/ tenofovir-alafenamide [Symtuza] 150/800/200/10mg/day. Subsequently, the patients developed cutaneous rash and thrombocytosis (1 patient), tonic-clonic seizures (1 patient), QT-prolongation (2 patients), diarrhoea (4 patients) and asthenia (1 patient) [durations of treatments to reactions onsets and outcomes not stated]. Cojutti PG, et al. Comparative Population Pharmacokinetics of Darunavir in SARS-CoV-2 Patients vs. HIV Patients: The Role of Interleukin-6. Clinical Pharmacokinetics 59: 803519660 1251-1260, No. 10, 2020. Available from: URL: http://doi.org/10.1007/s40262-020-00933-8

0114-9954/20/1833-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 5 Dec 2020 No. 1833