Cognitive Function After Lung Transplantation
Cognitive functioning after transplantation, which could influence medication compliance and independence, has not been well studied. This study investigated cognitive impairment after lung transplantation. Patients undergoing bilateral transplant between
- PDF / 191,487 Bytes
- 11 Pages / 504.567 x 720 pts Page_size
- 90 Downloads / 269 Views
Cognitive Function After Lung Transplantation Urte Sommerwerck, Daniel Jokisch, Gerhard Weinreich, Michael Neurath, Celina Heinze, Vasiliki Bessa, Clemens Aigner, Markus Kamler, Christian Taube, Kurt Rasche, Wolfram Windisch, and Martha Jokisch Abstract
Cognitive functioning after transplantation, which could influence medication compliance and independence, has not been well studied. This study investigated cognitive impairment after lung transplantation. Patients undergoing bilateral transplant between March 2013 and October 2015 underwent comprehensive neuropsychological assessment at 60.1 44.1 months post-transplantation: verbal memory (AuditoryVerbal Learning Test, digit span forward), visual memory (Corsi Block-Tapping Test forward,
Urte Sommerwerck and Daniel Jokisch contributed equally to this work. U. Sommerwerck (*) Department of Pneumology, Krankenhaus der Augustinerinnen Cologne, Cologne, Germany Department of Pneumology, Bergisches Lungenzentrum Wuppertal, Helios University Hospital of Wuppertal, University of Witten-Herdecke, Wuppertal, Germany e-mail: [email protected] D. Jokisch (*) and M. Jokisch Department of Neurology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany G. Weinreich, M. Neurath, C. Heinze, V. Bessa, and C. Taube Ruhrlandklinik, West German Lung Transplantation Centre, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany
Benton Visual Retention Test), concentration/ speed of processing/attention (D2 Test of Attention, Trail Making Test (TMT) A, Grooved Pegboard), and executive functioning (TMT B, Stroop Color-Word Test, semantic and phonematic verbal fluency, digit span backward, Corsi Block-Tapping Test backward). Mean scores were compared with a normative dataset using a one-sample t-test. A cognitive domain was judged impaired if the score on two or more domain-specific tests was greater than one standard deviation below the normative dataset age range mean. Of 124 lung transplant recipients (51% male, 54.3 9.0 years), 70% showed cognitive impairment in one or more domains.
C. Aigner Department of Thoracic Surgery, West German Lung Transplantation Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany M. Kamler Department of Thoracic and Cardiovascular Surgery, West German Heart Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany K. Rasche Department of Pneumology, Bergisches Lungenzentrum Wuppertal, Helios University Hospital of Wuppertal, University of Witten-Herdecke, Wuppertal, Germany W. Windisch Department of Pneumology, Cologne Merheim Hospital, Kliniken der Stadt Köln g GmbH, University of WittenHerdecke, Witten, Germany
U. Sommerwerck et al.
Executive function was most often impaired (78% of recipients not within the age range) followed by verbal memory impairment (72% not within the age range). Cognitive function reductions were largely independent of age, gender, education, immunosuppressive medications, and time since transplantation. The findings sh
Data Loading...