Collaboration of Colorado Cancer Genetic Counselors to Integrate Next Generation Sequencing Panels into Clinical Practic
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NEXT GENERATION GENETIC COUNSELING
Collaboration of Colorado Cancer Genetic Counselors to Integrate Next Generation Sequencing Panels into Clinical Practice K. Wolfe Schneider & A. Anguiano & L. Axell & C. Barth & K. Crow & M. Gilstrap & B. A. Hamlington & S. Lesh & L. Mullineaux & A. Kulchak Rahm & E. Strait & M. Freivogel
Received: 28 June 2013 / Accepted: 25 March 2014 # National Society of Genetic Counselors, Inc. 2014
Abstract The recent introduction of clinically available next generation sequencing (NGS) cancer panels has presented new challenges for genetic counselors. Determining which patients are appropriate for NGS panel testing is complex. Due to the large number of genes included in the NGS panels, thorough and appropriate pre-test counseling and interpretation of NGS results can be a time-consuming and difficult process. Many of the genes associated with increased cancer risk lack published clinical management guidelines and estimates of cancer risk for individuals with deleterious mutations. In order to efficiently and effectively review the clinical utility of NGS panels, Colorado cancer genetic counselors
formed a working group to gain a better understanding of the genes included in NGS cancer panels. This publication reports on the approach of this group, the process used to evaluate a selected NGS panel, future directions for this collaboration, and ideas for other genetic counselors to form similar groups to efficiently evaluate new technologies and improve practice.
K. Wolfe Schneider Department of Pediatrics, University of Colorado, Aurora, CO, USA
S. Lesh Genetic Counseling Services, Exempla Saint Joseph Comprehensive Cancer Center, Denver, CO, USA
A. Anguiano : M. Freivogel Risk Assessment and Prevention Program, Invision Sally Jobe, Greenwood Village, CO, USA L. Axell Comprehensive Cancer Center, University of Colorado, Aurora, CO, USA C. Barth Regional Cancer Center, St. Mary’s Hospital, Grand Junction, CO, USA K. Crow Hereditary Cancer Service, Dorcy Cancer Center, St. Mary-Corwin Medical Center, Pueblo, CO, USA M. Gilstrap Genetic Counseling Clinic, Porter Adventist Hospital, Denver, CO, USA B. A. Hamlington Rocky Mountain Cancer Centers, US Oncology, Denver, CO, USA
Keywords Next generation sequencing . Genetic testing . Genetic counselor collaboration . Inherited cancer . Hereditary cancer . Clinical utility
S. Lesh Genetic Counseling Services, Exempla Good Sam Medical Center, Lafayette, CO, USA L. Mullineaux Mile High Oncology, Littleton Adventist Hospital, Littleton, CO, USA A. K. Rahm Adult Genetic Services, Kaiser Permanente, Denver, CO, USA E. Strait Hereditary Cancer Service, Penrose Cancer Center, Colorado Springs, CO, USA K. Wolfe Schneider (*) Center for Cancer and Blood Disorders, Children’s Hospital Colorado, 13123 E. 16th Ave, B115, Aurora, CO 80045, USA e-mail: [email protected]
Wolfe Schneider et al.
Introduction In recent years, next-generation sequencing (NGS) has become a cost effective technology to evaluate multiple genes when compared to traditional
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