Common Variants in HLA-DRA Gene are Associated with Alcohol Dependence in Two Caucasian Samples

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Common Variants in HLA-DRA Gene are Associated with Alcohol Dependence in Two Caucasian Samples Yue Pan & Ke-Sheng Wang & Liang Wang & Long-Yang Wu

Received: 25 July 2012 / Accepted: 31 July 2012 / Published online: 14 August 2012 # Springer Science+Business Media, LLC 2012

Abstract HLA-DRA gene polymorphisms might play an important role in alcohol dependence (AD). We examined genetic associations of 29 single-nucleotide polymorphisms (SNPs) within the HLA-DRA gene with AD using two Caucasian samples—the Collaborative Study on the Genetics of Alcoholism (COGA) sample (660 AD cases and 400 controls) and the Study of Addiction: Genetics and Environment (SAGE) sample (623 cases and 1,016 controls). Logistic regression analysis using PLINK showed that 16 SNPs were associated with AD in the COGA sample and 13 SNPs were associated with AD in the SAGE sample (p

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