Community-based study of the association of subclinical thyroid dysfunction with blood pressure
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ORIGINAL PAPER
Community-based study of the association of subclinical thyroid dysfunction with blood pressure Yu Duan Æ Wen Peng Æ Xiaodong Wang Æ Wei Tang Æ Xiaoyun Liu Æ Shuhang Xu Æ Xiaodong Mao Æ Shangyong Feng Æ Yu Feng Æ Youwen Qin Æ Kuanfeng Xu Æ Cuiping Liu Æ Chao Liu
Received: 19 September 2008 / Accepted: 20 November 2008 / Published online: 7 January 2009 Ó Humana Press Inc. 2009
Abstract The relationship between subclinical thyroid dysfunction and blood pressure has been controversial and received unsufficient attention. Thus, we performed a cross-sectional study conducted among 6,992 inhabitants from six districts of Jiangsu Province to investigate the association of subclinical thyroid dysfunction with blood pressure in China. The data from 6,583 subjects (4,115 women and 2,468 men) were included and divided into three groups: euthyroidism (n = 5669, 86.11%), subclinical hyperthyroidism (n = 108, 1.65%), and subclinical hypothyroidism (n = 806, 12.24%). In the groups with subclinical hypothyroidism and hyperthyroidism, systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure were not significantly different from those in the groups with euthyroidism after being adjusted for age, sex, BMI, and smoking status (P [ 0.05). More extensively, the SBP and DBP in the group of subclinical hypothyroidism with lower level of TSH (TSH 4.51– 10.00 mIU/l, SCH1) were significantly higher than those of participants with euthyroidism (P \ 0.05). Multivariable logistic analysis revealed that subclinical hypothyroidism with lower TSH (TSH 4.51–10.00 mIU/l) was an independent risk factor for increased SBP (OR = 1.28, 95% CI 1.03–1.59, P = 0.028). Similar results could not be found between groups of euthyroid and subclinical hypothyroid with higher level of TSH (TSH [ 10 mIU/l, SCH2). Further subdivision of the euthyroid group on the basis of a TSH cut-off of 2.5 mIU/l, revealed still no significant difference in blood pressure after adjustment regardless of
Y. Duan W. Peng X. Wang W. Tang X. Liu S. Xu X. Mao S. Feng Y. Feng Y. Qin K. Xu C. Liu C. Liu (&) Department of Endocrinology, First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Rd, 210029 Nanjing, China e-mail: [email protected]
whether the TSH levels were in the lower reference (TSH 0.40–2.50 mIU/l, n = 4093) or in the upper reference ranges (TSH 2.51–4.50 mIU/l, n = 1576) (P [ 0.05). We concluded that subclinical thyroid dysfunction was not associated with blood pressure. Neither subclinical hyperthyroidism nor subclinical hypothyroidism independently predicted increased blood pressure. Keywords Subclinical hypothyroidism Subclinical hyperthyroidism Euthyroidism Blood pressure Hypertension
Introduction About 200 years ago, C. Parry noticed that thyroid goiter was possibly associated with heart failure [1]. Since then, researchers have found that thyroid function has profound effects on the cardiovascular system, and both hyperthyroidism and hypothyroidism were related to cardiovascular
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