Comparative analysis of density histograms and visual scores in incremental and volumetric high-resolution computed tomo
- PDF / 1,508,407 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 46 Downloads / 132 Views
COMPUTED TOMOGRAPHY
Comparative analysis of density histograms and visual scores in incremental and volumetric high‑resolution computed tomography of the chest in idiopathic pulmonary fibrosis patients Gaetano Rea1 · Marina De Martino2 · Annalisa Capaccio2 · Pasquale Dolce3 · Tullio Valente1 · Sabrina Castaldo2 · Angelo Canora2 · Francesco Lassandro1 · Marialuisa Bocchino2 Received: 31 May 2020 / Accepted: 15 November 2020 © The Author(s) 2020
Abstract Background Volumetric high-resolution computed tomography (HRCT) of the chest has recently replaced incremental CT in the diagnostic workup of idiopathic pulmonary fibrosis (IPF). Concomitantly, visual and quantitative scores have been proposed for disease extent assessment to ameliorate disease management. Purpose To compare the performance of density histograms (mean lung attenuation, skewness, and kurtosis) and visual scores, along with lung function correlations, in IPF patients submitted to incremental or volumetric thorax HRCT. Material and methods Clinical data and CT scans of 89 newly diagnosed and therapy-naive IPF patients were retrospectively evaluated. Results Forty-six incremental and 43 volumetric CT scans were reviewed. No differences of density histograms and visual scores estimates were found by comparing two HRCT techniques, with an optimal inter-operator agreement (concordance correlation coefficient >0.90 in all instances). Single-breath diffusing lung capacity for carbon monoxide (DLCOsb) was inversely related with the Best score (r = −00.416; p = 0.014), the Kazerooni fibrosis extent (r = −0.481; p = 0.004) and the mean lung attenuation (r = −0.382; p = 0.026), while a positive correlation was observed with skewness (r = 0.583; p = 0.001) and kurtosis (r = 0.543; p = 0.001) in the incremental HRCT sub-group. Similarly, in the volumetric CT sub-cohort, DLCOsb was significantly associated with skewness (r = 0.581; p = 0.007) and kurtosis (r = 0.549; p = 0.018). Correlations with visual scores were not confirmed. Forced vital capacity significantly related to all density indices independently on HRCT technique. Conclusions Density histograms and visual scores similarly perform in incremental and volumetric HRCT. Density quantification displays an optimal reproducibility and proves to be superior to visual scoring as more strongly correlated with lung function. Keywords Idiopathic pulmonary fibrosis · Tomography · Densitometry · Visual score
Introduction
* Marialuisa Bocchino [email protected] 1
Dipartimento Dei Servizi Diagnostici E Generali, Ospedali dei Colli, Monaldi-Cotugno, Napoli, Italy
2
Dipartimento Di Medicina Clinica E Chirurgia, Sezione Di Malattie Dell’Apparato Respiratorio, Università Federico II, Napoli, Italy
3
Dipartimento Di Sanità Pubblica, Università Federico II, Napoli, Italy
High-resolution computed tomography (HRCT) of the chest represents the milestone for the identification of differential patterns in the field of diffuse interstitial lung diseases (ILDs). HRCT is pivotal for disease di
Data Loading...
