Comparative Genomics International Workshop, RECOMB-CG 2008, Paris,

This book constitutes the refereed proceedings of the 6th RECOMB Comparative Genomics Satellite Workshop, RECOMB-CG 2008, held in Paris, France, in October 2008. The 19 revised full papers presented were carefully reviewed and selected from 48 initia

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Craig E. Nelson Stéphane Vialette (Eds.)

Comparative Genomics International Workshop, RECOMB-CG 2008 Paris, France, October 13-15, 2008 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Craig E. Nelson University of Connecticut Division of Genetics and Genomics, Molecular and Cell Biology Beach Hall, 354 Mansfiled Rd, Storrs, CT 06269, USA E-mail: [email protected] Stéphane Vialette Université Paris-Est, IGM-LabInfo UMR 8049 5 Bd Descartes, Champs sur Marne, 77454 Marne la Vallée, France E-mail: [email protected]

Library of Congress Control Number: 2008936578

CR Subject Classification (1998): F.2, G.3, E.1, H.2.8, J.3 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-540-87988-9 Springer Berlin Heidelberg New York 978-3-540-87988-6 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2008 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 12533763 06/3180 543210

Preface

Over the last decade great investments have been made in the acquisition of enormous amounts of gene sequence data from a diverse collection of organisms. Realizing the full potential of these investments will require the continued development of computational tools for comparative genomics and the intelligent application of these tools to address biologically relevant questions. The RECOMB Workshop on Comparative Genomics (RECOMB-CG) is devoted to bringing together scientists working on all aspects of comparative genomics, from the development of new computational approaches to genome sequence analysis and comparison, to the genome-wide application of computational tools to study the evolutionary dynamics of prokaryotic and eukaryotic genomes. This volume contains the 19 papers presented at the 6th Annual RECOMB´ CG workshop held during October 13–15 at the Ecole Normale Sup´erieure, in Paris, France. The papers selected for pr