Comparison of amide proton transfer imaging and magnetization transfer imaging in revealing glioma grades and proliferat
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DIAGNOSTIC NEURORADIOLOGY
Comparison of amide proton transfer imaging and magnetization transfer imaging in revealing glioma grades and proliferative activities: a histogram analysis Changliang Su 1
&
Jingjing Jiang 2 & Chengxia Liu 2 & JingJing Shi 2 & Shihui Li 2 & Xiaowei Chen 3 & Qilin Ao 4
Received: 24 June 2020 / Accepted: 31 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Comprehensive understanding glioma metabolic characters is of great help for patient management. We aimed to compare amide proton transfer imaging (APTw) and magnetization transfer imaging (MT) in predicting glioma malignancy and reflecting tumor proliferation. Methods Thirty low-grade gliomas (LGGs) and 39 high-grade gliomas (HGGs) were prospectively included, of which 58 samples Ki-67 levels were quantified. Anatomical MRI, APTw, and MT were scanned, and magnetization transfer ratio (MTR) and asymmetric magnetic transfer ratio at 3.5 ppm (MTRasym(3.5ppm)) were calculated. ROIs were semi-automatically drawn with ImageJ, from which histogram features, including 5th, 25th, 50th, mean, 70th, 90th, and 95th percentiles were extracted. The independent t test was used to test differences in LGGs and HGGs, and correlations between histogram features and tumor grades, Ki-67 were revealed by Spearman’s rank or Pearson’s correlation analysis. Results The maximum correlation coefficient (R) values of APTw were 0.526 (p < 0.001) with tumor grades and 0.397 (p < 0.001) with Ki-67 at 90th percentiles, while only 5th and 25th percentiles of MT significantly correlated with tumor grades. Moreover, APTw features were significantly different in LGGs and HGGs, except 5th percentile. The most significantly different feature was 95th percentile, providing the excellent AUC of 0.808. However, the best feature in MTR was 5th percentiles with AUC of 0.703. Combing 5th and 95th of APTw achieved highest AUC Of 0.837. Conclusions Both APTw and MT provide quantitative information for tumor metabolite imaging. However, APTw supplys more specific information in reflecting glioma biological behaviors than MT, and well differentiates glioma malignancy. Keywords Magnetic resonance imaging . Amide proton transfer imaging . Magnetization transfer imaging . Tumor grading . Tumor proliferation
CS and JJ contributed equally to this work. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00234-020-02547-0) contains supplementary material, which is available to authorized users. * Changliang Su [email protected] 1
Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
2
Department of Radiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, Hankou, Wuhan 430030, People’s Republic of China
3
The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Chin
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