Comparison of Antithrombotic Strategies in Chinese Patients in Sinus Rhythm after Bioprosthetic Mitral Valve Replacement
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ORIGINAL ARTICLE
Comparison of Antithrombotic Strategies in Chinese Patients in Sinus Rhythm after Bioprosthetic Mitral Valve Replacement: Early Outcomes from a Multicenter Registry in China Heng Zhang 1 & Yijun Dong 2 & Xuelian Ao 3 & Bo Fu 4 & Li Dong 1 & on behalf of the CLIATHVR (Chinese Low Intensity Anticoagulant Therapy After Heart Valve Replacement) multicenter clinical study team Accepted: 1 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Objectives To compare antithrombotic strategies in Chinese patients undergoing bioprosthetic mitral valve implantation discharged in normal sinus rhythm. Methods At 28 hospitals in China, 1603 patients were followed for 2991.5 person-years. Adverse event and death rates during five postoperative time intervals (≤ 30, 31–90, 91–180, 181–365, and 366–730 days) were calculated in patients administered warfarin, aspirin, warfarin + aspirin, or neither treatment. Results Thromboembolic and hemorrhagic events occurred in 22 (0.74/100 patient-years, 95%CI 0.43–1.05) and 28 (0.94/100 patient-years, 95%CI 0.59–1.29) patients, respectively. In the first 3 months post-surgery, warfarin-treated patients had significantly lower rates of thromboembolic events than the aspirin or untreated groups (P = 0.01, P
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