Comparison of Image Quality and Semi-quantitative Measurements with Digital PET/CT and Standard PET/CT from Different Ve
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ORIGINAL ARTICLE
Comparison of Image Quality and Semi-quantitative Measurements with Digital PET/CT and Standard PET/CT from Different Vendors Sung Hoon Kim 1,2
&
Bong-Il Song 2
&
Hae Won Kim 2
&
Kyoung Sook Won 2
Received: 22 May 2020 / Revised: 13 July 2020 / Accepted: 4 August 2020 # Korean Society of Nuclear Medicine 2020
Abstract Purpose This study aimed to evaluate the concordance and equivalence of results between the newly acquired digital PET/ CT(dPET) and the standard PET/CT (sPET) to investigate possible differences in visual and semi-quantitative analyses. Methods A total of 30 participants were enrolled and underwent a single 18F-FDG injection followed by dual PET/CT scans, by a dPET scan, and immediately after by the sPET scan or vice versa. Two readers reviewed overall image quality using a 5-point scale and counted the number of suggestive 18F-FDG avid lesions. The SUV values were measured in the background organs and in hypermetabolic target lesions. Additionally, we objectively evaluated image quality using the liver signal-to-noise ratio (SNR). Results The dPET identified 4 additional 18F-FDG avid lesions in 3 of 30 participants with improved visual image quality. The standard deviations of SUV of the background organs were significantly lower with DigitalPET than with sPET, and dPET could acquire images with better SNR (11.13 ± 2.01 vs. 8.71 ± 1.32, P < 0.001). The reliability of SUV values between scanners showed excellent agreement. Bland-Altman plot analysis of 81 lesions showed an acceptable agreement between scanners for most of the SUVmax and SUVpeak values. No relationship between the SUV values and time delays of dual PET/CT acquisition was found. Conclusions The dPET provides improved image quality and lesion detectability than the sPET. The semi-quantitative values of the two PET/CT systems of different vendors are comparable. This pilot study will be an important basis for possible interchangeable use of either system in clinical practice. Keywords Digital PET . PET/CT . 18F-FDG . SiPM . Silicon photomultiplier . Image quality
Introduction Positron emission tomography/computed tomography (PET/ CT) is a well-established functional imaging modality, with
* Kyoung Sook Won [email protected] Sung Hoon Kim [email protected] Bong-Il Song [email protected] Hae Won Kim [email protected] 1
Department of Nuclear Medicine, Keimyung University Daegu Dongsan Hospital, Daegu, South Korea
2
Department of Nuclear Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, 1095 Dalgubeol-daero, Dalseo-gu, Daegu 42601, Republic of Korea
maximal applications in oncology (94%), cardiology (3%), and neurology (3%) [1]. Presently, the most commonly used tracer for PET/CT is 18F-fluorodeoxyglucose (18F-FDG), and 18 F-FDG PET/CT has become a popular method for detection, staging, restaging, and response evaluation in oncology [2]. Technical advances in PET instrumentation, in terms of photon sensitivity and spatial and timing resolutions, are expected to enhance dete
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