Comparisons of optic nerve head morphology parameters between the presence and absence of silent brain infarctions
- PDF / 159,170 Bytes
- 2 Pages / 595.276 x 790.866 pts Page_size
- 91 Downloads / 206 Views
LETTER TO THE EDITOR
Comparisons of optic nerve head morphology parameters between the presence and absence of silent brain infarctions Katsunori Hara 1 & Ichiya Sano 1 & Atsushi Nagai 2 & Masaki Tanito 1 Received: 10 September 2020 / Revised: 2 November 2020 / Accepted: 6 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Dear Editor, Glaucomatous optic neuropathy, optic nerve damage due to retinal ganglion cell (RGC) and RGC axon loss, is characterized by enlargement of the optic nerve head (ONH) cup-todisc (C/D) ratio and thinning of the rim-to-disc (R/D) ratio [1]. A possible link between glaucoma and brain pathologies such as brain infarctions and dementia has been suspected [2–4]; however, few reports have assessed the association between brain pathologies and changes in the ONH morphology. We compared the planimetrically obtained ONH parameters between subjects with and without silent brain infarctions (SBIs). The Institutional Review Board of the Shimane University Faculty of Medicine approved this study (IRB No. 201602171), which was conducted according to the tenets of the Declaration of Helsinki. Each participant provided written consent. The cohort database included 2287 Japanese subjects who participated in a health examination program in the Shimane Institute of Health Science from 20 April 2005 to 13 February 2013 [5]. We enrolled 1944 subjects from the database for whom color fundus photographs of the right eye and brain magnetic resonance imaging (MRI) were available and who had no history of a symptomatic brain stroke. Color fundus photographs were obtained using a nonmydriatic fundus camera (CR6-45NM, Canon, Tokyo, Japan) with a 45° view angle. The vertical C/D ratio, minimal R/D ratio, and disc-macular distance to disc diameter (DM/ DD) ratio were calculated using the C/D Sketch software (available at http://www.kowa.co.jp/e/life/app_download/.)
* Masaki Tanito [email protected] 1
Department of Ophthalmology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan
2
Department of Neurology, Shimane University Faculty of Medicine, Izumo, Japan
as described previously [6]. Brain MRI scans were performed using the 1.5-Tesla MRI system (Symphony Ultra Gradient, Siemens). The each patient’s head was scanned with T2-weighted (T2WI; TR = 4500 ms; TE = 86 ms), T1-weighted (T1WI; TR = 2500 ms; TE = 3.9 ms), and FLAIR (TR = 8000 ms; TE = 92 ms) images. Experienced neurologists defined SBIs as focally hyperintensity lesions larger than 3 mm in diameter in the T2WI images, corresponding to a hypointense lesion in the T1WI; FLAIR images were used to differentiate infarcts from enlarged perivascular spaces [7]. As result, a SBI was found in 273 (14%) subjects. Compared with the group without SBIs (SBI-), the C/D ratio was significantly larger (p = 0.0209) and the R/D ratio was significantly smaller (p = 0.0309) in the group with SBIs (SBI+), while the DM/DD ratios were equivalent between the groups (Table 1). Other than the C/D and R/D ratios, t
Data Loading...
