• PDF / 169,881 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 14 Downloads / 198 Views

DOWNLOAD

REPORT

---

1 S

Angioedema and lack of efficacy: case report A 58-year-old woman developed angioedema during treatment with ramipril for hypertension. Additionally, she exhibited lack of efficacy during treatment with icatibant and unspecified complement-c1-inhibitor for angioedema [routes, dosage and duration of treatment to reaction onset not stated]. The woman, who had been receiving ramipril for hypertension, presented to a rural hospital with stridor and cough. CT scan showed epiglottic swelling. C1inh function and level were normal. The woman was intubated, and she was treated with prednisone and unspecified antihistamines. With a diagnosis of ACEinhibitor-induced angioedema, ramipril was discontinued. However, for the following 7 months, she continued to present with stridor, due to which she was intubated many times. Tracheostomy was performed. Her history revealed possible angioedema, which had been affecting for several generations. She was diagnosed with hereditary angioedema with normal C1 inhibitor (HAE-nC1inh). Tests for genetic variations were negative. She received prophylactic treatment with danazol, tranexamic acid and unspecified complement-c1-inhibitor [C1 inhibitor]. She continued to have daily attacks. She showed minimal response to icatibant and unspecified complement-c1-inhibitor. Thereafter, she was transferred to a tertiary care for reassessment, where vocal cord dysfunction (VCD) was discovered. Her subsequent stridor attacks after the initial angioedema were thought to be due to VCD [outcome not stated]. Lo SCR, et al. Angiotensin-converting enzyme inhibitor-induced angioedema with vocal cord dysfunction, a case of a combination of diagnoses masquerading as hereditary angioedema with normal C1 inhibitor. Allergy, Asthma and Clinical Immunology 16 (Suppl.): abstr. 23, 2020. Available from: URL: http://doi.org/10.1186/ 803515289 s13223-020-00445-x [abstract]

0114-9954/20/1830-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 14 Nov 2020 No. 1830