Comprehensive analysis reveals a six-gene signature and associated drugs in mimic inguinal hernia model
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ORIGINAL ARTICLE
Comprehensive analysis reveals a six‑gene signature and associated drugs in mimic inguinal hernia model B. Zhao1,2 · Z. Wan1,2 · J. Wang3 · H. Liu1,2 · Y. Zhou1,2 · W. Chen1,2 · X. Zhang1,2 · Y. Wang4 · L. Xiao1,2 · Y. Zhao1 Received: 13 April 2020 / Accepted: 4 May 2020 © Springer-Verlag France SAS, part of Springer Nature 2020
Abstract Purpose Inguinal hernia often occurs in elderly men, and more than one in five men will undergo inguinal hernia repair during their lifetime. Nevertheless, the underlying molecular mechanisms of the pathogenesis behind hernia formation is still unclear. The aims in this study are finding out the potential gene markers and available drugs. Methods Firstly, we re-analyzed the GSE92748 datasets, including four high and four low expressions of humanized aromatase transgenic mice, which refers to mimic humanized hernia, to identify differentially expressed genes (DEGs) in AromhumH group compared with AromhumL group by the criteria: fold change ≥ 1.4 and adjust P value
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