Computational Systems Neurobiology
Computational neurosciences and systems biology are among the main domains of life science research where mathematical modeling made a difference. This book introduces the many different types of computational studies one can develop to study neuronal sys
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Nicolas Le Nov`ere Editor
Computational Systems Neurobiology
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Editor Nicolas Le Nov`ere European Molecular Biology Laboratory European Bioinformatics Institute Welcome-Trust Genome Campus Hinxton, Cambridge United Kingdom
ISBN 978-94-007-3857-7 ISBN 978-94-007-3858-4 (eBook) DOI 10.1007/978-94-007-3858-4 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2012943348 © Springer Science+Business Media Dordrecht 2012 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publishers location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
It is now well accepted that the concept “one gene-one protein-one function” is largely inadequate to understand life. The corresponding biomedical concept “one gene-one phenotype-one disease” is even more problematic. Many diseases are multifactorial, but moreover, mono- or multifactorial, the expression of almost all dysfunctions depends on the person and its environment. Systems Biology is a discipline born after second world war, based on control theory, in particular cybernetics, and systems theory. Systems Biology can be briefly summarised as the study of the emerging properties of a biological system taking into account all the necessary constituents, their relationships and their temporal variation. It relies on integration between experimental observa
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