Computer-aided retinal vessel segmentation in retinal images: convolutional neural networks

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Computer-aided retinal vessel segmentation in retinal images: convolutional neural networks Esin Uysal 1 & Gür Emre Güraksin 1 Received: 30 September 2019 / Revised: 10 July 2020 / Accepted: 16 July 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract

In medicine, diagnosis is as important as treatment. Retinal blood vessels are the most easily visible vessels in the whole body, and therefore, play a key role in the diagnosis of numerous diseases and eye disorders. Systematic and eye diseases cause morphologic variations, such as the growing, narrowing or branching of retinal blood vessels. Imagingbased screening of retinal blood vessels plays an important role in the identification and follow-up of eye diseases. Therefore, automatic retinal vessel segmentation can be used to diagnose and monitor those diseases. Computer-aided algorithms are required for the analysis of progression of eye diseases. This study proposes a hybrid method that provides a combination of pre-processing and data augmentation methods with a deep learning model. Pre-processing was used to solve the irregular clarification problems and to form a contrast between the background and retinal blood vessels. After pre-processing step, a convolutional neural network (CNN) was designed and then trained for the extraction of retinal blood vessels. In the training phase, data augmentation was performed to improve training performance. The CNN was trained and tested in the DRIVE database, which is commonly used in retinal blood vessel segmentation and publicly available for studies in this area. Results showed that the proposed system extracted vessels with a sensitivity of 77.78%, specificity of 97,84%, precision of 84.17% and accuracy of 95.27%. This study also compared the results to those of previous studies. The comparison showed that the proposed method is an efficient and successful method for extracting retinal blood vessels. Moreover, the pre-processing phases improved the system performance. We believe that the proposed method and results will make contribution to the literature. Keywords Retinal blood vessel segmentation . Convolutional neural network . Image segmentation . Deep learning . Image processing

* Gür Emre Güraksin [email protected]

1

Department of Biomedical Engineering, Afyon Kocatepe University, Afyonkarahisar, Turkey

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1 Introduction In medicine, diagnosis is as important as treatment. However, providing the fastest and most accurate diagnosis is an important parameter as well. Advances in technology allow us to provide faster and more accurate solutions to current problems. For example, different types of technological devices are used to diagnose a variety of diseases. Generally, x-rays are used for bone and hard tissues, tomography for soft tissues, and fundus cameras for retinal imaging. They are also complementary devices that help doctors to diagnose diseases. The retina is a light-sensitive tissue that consists of photosensitive cells (photorece