COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts
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ORIGINAL ARTICLE
COMT rs4818, pain sensitivity and duration, and alveolar bone grafting of oral clefts E. M. V. M. Silva 1 & R. H. W. Lacerda 1 & I. L. Farias 1 & B. G. N. Cavalcante 1 & I. O. Assis 1 & M. Bezamat 2 & A. Modesto 3 & Alexandre Rezende Vieira 1,2 Received: 7 July 2020 / Accepted: 22 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Verifying whether the mutation in COMT rs4818 could be involved in pain modulation. Methods Thirty-two individuals born with cleft lip and palate that underwent bone graft from the iliac crest bone were assessed at 12, 24, 48, 72 h, and 7 days regarding their pain experience using a visual analogic scale. DNA from each participant was collected from saliva samples, and genotyping of rs4818 was performed using TaqMan chemistry. Overrepresentation of rs4818 alleles was tested using chi-square or Fisher’s exact tests with an alpha of 0.05. Results Of the 32 individuals, eighteen reported long pain duration, nine reported high pain intensity, and fourteen low pain intensity up to 48 h. No differences were found in the distribution of individuals depending on the reported pain by sex (p = 0.12), age (p = 0.42), or cleft type (p = 0.5). The distribution of COMT r4818 alleles was different depending on the intensity and duration of pain. Carriers of the C wild-type allele were four times more likely to show high pain intensity and duration (odds ratio = 4.29, 95% confidence interval 1.13–16.18), meaning that the G variant allele is protective. Conclusion COMT rs4818 is associated with postoperative pain after alveolar bone grafting. Keywords Pain . Genetics . COMT . Bone graft . Cleft lip and palate
Introduction There is evidence that postoperative pain rates of surgical treatment of individuals born with cleft lip and palate varies dramatically [1–3]. One mechanism that apparently influences pain response throughout the lifespan is our endogenous μopioid system and how our genetic profile impacts its activation. Genetic variation in catechol-O-methyltransferase (COMT) apparently can serve as a biomarker for pain
* Alexandre Rezende Vieira [email protected] 1
Post-graduate Program in Dentistry and Center for Treatment of Cleft Lip and Palate, University Hospital Lauro Wanderley, Universidade Federal da Paraíba, João Pessoa, PB, Brazil
2
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 412 Salk Pavilion, 335 Sutherland Street, Pittsburgh, PA 15261, USA
3
Department of Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
responses. Studies on temporomandibular joint dysfunction (TMD) [4–8], TMD associated with other arthralgias [9] the interaction of TMD with stress and anxiety [10, 11], dental pulp sensitivity [12, 13], knee pain in persons with osteoarthritis [14, 15], low back pain [16–18], fibromyalgia [19], distal neuropathic pain due to HIV-associated sensory neuropathy [20], and opioid efficacy in children and adults [21], support this assumption. Of spe
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