Contemporary Issues in Modeling Psychopathology
Despite considerable progress in clinical and basic neurosciences, the cure of psychiatric disorders is still remote, little is known about their prevention, and the etiology and molecular mechanisms of mental disorders are still obscure. Diagnoses are st
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NEUROBIOLOGICAL FOUNDATION OF ABERRANT BEHAVIORS Editorial Board: MICHAEL MYSLOBODSKY Tel-Aviv University & Howard University STANLEY D. GLICK Albany Medical College SEYMOUR S. KETY Harvard University & McLean Hospital MORRIS MOSCOVITCH University of Toronto DANIEL R. WEINBERGER National Institutes of Health I National Institute of Mental Health
CONTEMPORARY ISSUES IN MODELING PSYCHOPATHOLOGY
edited by
Michael S. Myslobodsky Tel Aviv University & Howard University Ina Weiner Tel Aviv University
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data Contemporary issues in modeling psychopathology / edited by Michael S. Myslobodsky, and Ina Weiner. p. cm. - (Neurobiologica! foundation of aberrant behaviors ; 1) Includes bibliographica! references and index. ISBN 978-1-4419-4996-7 ISBN 978-1-4757-4860-4 (eBook) DOI 10.1007/978-1-4757-4860-4
1. Psychology, pathologica!. 2. Biologica! models. 3. Biologica! psychiatry. 4. Mental disorders. 1. Myslobodsky, Michael. IIWeiner, Ina, 1949-. m Series. [DNLM: WM 102 C761 2000] RC465 .C65 2000 00-059275 616.89 - dc21
Copyright ~ 2000 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2000 AlI rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permission ofthe publisher, Springer Science+Business Media, LLC.
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TABLE OF CONTENTS 1.
Involvement of Dopamine Transporters in Psychiatric Disorders Gary W. Miller, Raul R. Gainetdinov and Marc G. Caron ..................... I
2.
The Long-Term Behavioral and Neurobiological Consequences of Treatment with Psychomotor Stimulant Drugs: Implications for Psychopathology Terry E. Robinson .................................................................................. 19
3.
Anxiety and Impulse Control in Rats Selectively Bred for Seizure Susceptibility Dan C. McIntyre and Hymie Anisman .................................................... 29
4.
Behavioral and Neurohormonal Sequelae of Prenatal Stress: a Suggested Model of Depression Marta Weinstock ................................................................................... 45
5.
Promises and Limitations of Transgenic and Knockout Mice in Modeling Psychiatric Symptoms Andrew Holmes and Jacqueline N. Crawley .......................................... 55
6.
Viral Mechanisms of Schizophrenia Bradley D. Pearce ................................................................................... 79
7.
Prepulse Inhibition as a Cross-Species Model of Sensorimotor Gating Deficits in Schizophrenia MarkA. Geyer ............... ~ ........................................................................ 103
8.
Neural Systems Involved in Fear Inhibition: Extinction and Conditioned Inhibition
