Coronary flow reserve and relative flow reserve measured by N-13 ammonia PET for characterization of coronary artery dis
- PDF / 994,642 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 112 Downloads / 188 Views
ORIGINAL ARTICLE
Coronary flow reserve and relative flow reserve measured by N-13 ammonia PET for characterization of coronary artery disease Sang-Geon Cho1 • Ki Seong Park1 • Jahae Kim1 • Sae-Ryung Kang3 • Ho-Chun Song1 • Ju Han Kim2 • Jae Yeong Cho2 • Young Joon Hong2 • Zeenat Jabin3 • Hee Jeong Park3 • Geum-Cheol Jeong3 • Seong Young Kwon3 Jin Chul Paeng4 • Hyeon Sik Kim3 • Jung-Joon Min3 • Ernest V. Garcia5 • Henry Hee-Seung Bom3
•
Received: 24 July 2016 / Accepted: 7 November 2016 Ó The Japanese Society of Nuclear Medicine 2016
Abstract Objective We evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD). Methods Sixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVRref) were measured by N-13 ammonia PET. The presence of significant stenosis (SS) and diffuse atherosclerosis (DA) was evaluated on CCTA and CAG. Functional parameters measured by PET were compared among arteries with and without SS and DA. Results Arteries with SS and those with DA showed significantly lower stress MBF, as compared to those without. RFR was significantly lower in arteries with SS as
compared to those without, while CFR was not. CFR was significantly lower in arteries with DA as compared to those without, while RFR was not. Among arteries without SS, CFR was significantly lower in those with DA as compared to those without. However, among arteries with SS, CFR was similar between those with and without DA. In contrast, RFR was significantly lower in arteries with SS, regardless of the presence of DA. CFR and RFR showed a weak positive correlation (r = 0.269) with discordance in 24 cases (35%). Among the arteries with CFRRFR discordance, the prevalence of DA was significantly higher in those with low CFR but preserved RFR, as compared to those with preserved CFR but low RFR (75 vs 25%, p = 0.028). CVRref was significantly higher in arteries with DA, implicating a correlation of DA with underlying microvascular disease. Conclusions CFR and RFR measured by myocardial perfusion PET could provide a comprehensive information for characterization of epicardial CAD. Keywords Coronary artery disease Positron emission tomography Coronary flow reserve Relative flow reserve
& Henry Hee-Seung Bom [email protected] 1
Department of Nuclear Medicine, Chonnam National University Hospital, Gwang-ju, South Korea
2
Department of Cardiology, Chonnam National University Hospital, Gwang-ju, South Korea
3
Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, 322 Seoyang-ro Hwasun-eup, Hwasun-gun, Jeonnam 58128, South Korea
4
Department of Nuclear Medicine, Seoul National University Hospital, Seoul, South Kor
Data Loading...
