Correction to: Molecular Interaction Networks to Select Factors for Cell Conversion
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Patrick Cahan Editor
Computational Stem Cell Biology Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Computational Stem Cell Biology Methods and Protocols
Edited by
Patrick Cahan Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
Editor Patrick Cahan Department of Biomedical Engineering Johns Hopkins University Baltimore, MD, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9223-2 ISBN 978-1-4939-9224-9 (eBook) https://doi.org/10.1007/978-1-4939-9224-9 © Springer Science+Business Media, LLC, part of Springer Nature 2019, corrected publication 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The title of this book, Computational Stem Cell Biology, bears some explanation. First, let me propose a definition. Computational stem cell biology (CSCB) is the field concerned with the generation and application of computational approaches to understand the unique properties of stem cells. One of the unique features of stem cells is, of course, their fate potency, a term that refers to the ability of a cell to select from and to become one of several distinct cell types. The other unique property of a stem cell is its ability to maintain its fate potency over time, often through many rounds of cell division—a process called selfrenewal. Now, we have a slightly more expanded definition of CSCB: the development and application of computation to understand the basis of fate poten
