Correction to: Physiologically Based Pharmacokinetic Modeling of CFTR Modulation in People with Cystic Fibrosis Transiti
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CORRECTION
Correction to: Physiologically Based Pharmacokinetic Modeling of CFTR Modulation in People with Cystic Fibrosis Transitioning from Mono or Dual Regimens to Triple-Combination Elexacaftor/Tezacaftor/ Ivacaftor Alice Tsai
. Shu-Pei Wu . Eric Haseltine . Sanjeev Kumar .
Samuel M. Moskowitz . Paul Panorchan . Kushal Shah To view enhanced content go to www.pulmonarytherapy-open.com Ó The Author(s) 2020
Correction to: Pulm Ther https://doi.org/10.1007/ s41030-020-00124-7 The original version of this article unfortunately contained a mistake. In section ‘‘Methods’’, the word ‘‘physiochemical’’ was incorrectly changed to ‘‘physicochemical’’ in four instances. The correct sentences are as follows: First sentence of subsection ‘‘Ivacaftor PBPK Model’’: The physiochemical properties of ivacaftor [e.g., permeability, blood-to-plasma ratio, plasma protein binding, logarithm of acid dissociation constant (pKa)] were obtained from internal sources. All ivacaftor PBPK model parameters are available in Supplementary Table S1. First sentence of subsection ‘‘Lumacaftor PBPK Model’’: The physiochemical properties of lumacaftor (e.g., permeability, blood-to-plasma ratio, plasma protein binding, pKa) were obtained from internal sources. First sentence of subsection ‘‘Tezacaftor PBPK Model’’: The physiochemical properties of tezacaftor (e.g., permeability, blood-to-plasma ratio,
The original article can be found online at https://doi. org/10.1007/s41030-020-00124-7. A. Tsai (&) S.-P. Wu E. Haseltine S. Kumar S. M. Moskowitz P. Panorchan K. Shah Vertex Pharmaceuticals Incorporated, Boston, MA, USA e-mail: [email protected]
plasma protein binding, pka) were obtained from internal sources. First sentence of subsection ‘‘Elexacaftor PBPK Model’’: The physiochemical and ADME properties of elexacaftor (e.g., permeability, blood-to-plasma ratio, plasma protein binding), as well as relevant clinical data, were obtained from internal sources. The original article has been corrected.
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