Correlates of fasting blood glucose among children living with hiv in a Nigerian tertiary hospital: a cross-sectional st
- PDF / 296,356 Bytes
- 7 Pages / 595.276 x 790.866 pts Page_size
- 70 Downloads / 169 Views
RESEARCH ARTICLE
Open Access
Correlates of fasting blood glucose among children living with hiv in a Nigerian tertiary hospital: a cross-sectional study Ijeoma Onyinye Ohuche1,2,3*, Ugo Nnenna Chikani2, Elizabeth Eberechi Oyenusi3,4,5, Justus Uchenna Onu6 and Abiola Oduwole3,4,5
Abstract Background: There is growing concern as regards the emergence of metabolic disorders among children living with the Human Immunodeficiency Virus (HIV) worldwide. However, there is paucity of data on the correlates of metabolic indices among HIV-positive children in Africa. Methods: This study examined 84 HIV-positive children on HAART recruited from the paediatric infectious diseases clinic of the University of Nigeria Teaching Hospital for blood glucose levels using finger-prick testing with an Accucheck glucose meter and test strips. Clinical information was obtained via clinical history and medical records. Data was analyzed to examine the relationship between FBG and the classes of HAART, duration of illness and treatment using analysis of variance (ANOVA). Results: FBG was significantly associated with the classes of HAART (x2=12.4, p = 0.017). In addition, there was a significant association between FBG and duration of illness [F(2, 81) = 6.0; P = 0.004], as well as FBG and duration on HAART [F(2, 81) = 7.9; P = 0.001]. However, duration on HAART and type of HAART were the significant predictors of FBG in this study accounting for 10.5% and 4.1% of the variance, respectively. Conclusions: There is a greater risk of dysglycemia in paediatric patients with a longer cumulative exposure to HAART. Routine blood glucose checks among children on HAART, especially those who have received HAART for a longer duration of time may therefore be useful in their management. Keywords: Fasting, blood glucose, HIV, Children
Background Nigeria has the second largest HIV pandemic burden worldwide, [1] and in 2017, accounted for half of all children and adolescents living with HIV in West and Central Africa [1]. These children are now more likely to survive and have longer lifespans, as a consequence of improved awareness and screening, as well as success with the use * Correspondence: [email protected] 1 Department of Paediatrics, Niger Foundation Hospital, Enugu, Nigeria 2 Department of Paediatrics, University of Nigeria Teaching Hospital, Enugu, Nigeria Full list of author information is available at the end of the article
of highly-active anti-retroviral therapy (HAART). However, increased survival of these patients has its implications, as this has been associated with a concurrent emergence of metabolic disorders over time [2–4]. These metabolic aberrations include disorders in glucose and lipid metabolism, as well as lactic acidosis, and have been largely associated with the use of HAART [4]. These metabolic disturbances carry with them, a series of risk factors for cardiovascular disease, such as central obesity, atherogenic dyslipidemia, hypertension, and impaired insulin and glucose metabolism with the risk of cardiovascular-r
Data Loading...
