Correlation analysis between serum procalcitonin and infarct volume in young patients with acute cerebral infarction
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ORIGINAL ARTICLE
Correlation analysis between serum procalcitonin and infarct volume in young patients with acute cerebral infarction Huijun Wen 1 & Maikou Lv 1 Received: 6 July 2020 / Accepted: 22 October 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Objective To detect the serum procalcitonin (PCT) level and determine its relationship with the infarct volume in young patients with acute cerebral infarction. Methods According to the infarct volume, young patients with acute cerebral infarction were divided into large group, intermediate group, and small group. The severity of clinical symptoms was determined according to the National Institute of Health Stroke Scale (NIHSS) score. Healthy young people were selected as the control group. Serum PCT levels were measured. The relationship among PCT, volume, and NIHSS score was analyzed. Results PCT in observation group was significantly higher than that in control group (t = 6.879, P = 0.011), and PCT in severe group was significantly higher than in mild group (t = 6.978, P = 0.016). PCT in large cerebral infarction group was higher than that in intermediate and small-size infarct group (P = 0.0036 and P < 0.0001, respectively), and PCT in intermediate cerebral infarction group was higher than that in small-size infarct group (P = 0.0024). In observation group, the PCT level was positively correlated with both NIHSS (r = 0.793, P = 0.022) and infarction volume (r = 0.649, P = 0.007). Conclusion The level of PCT in young patients with acute cerebral infarction may be related to the inflammatory reaction of the cerebral artery and positively related to the volume of cerebral infarction and NIHSS score. To some extent, PCT concentration can predict the disease severity of acute cerebral infarction. Keywords Procalcitonin . Acute cerebral infarction . Young . Infarct volume . Neurological deficit
Abbreviations PCT Procalcitonin NIHSS National Institute of Health Stroke Scale DWI Diffusion-weighted imaging BMI Body mass index ELISA Enzyme-linked immunosorbent assay EDTA Ethylenediaminetetraacetic acid AIS Acute ischemic stroke LCI Large cerebral infarction
* Maikou Lv [email protected]; [email protected] 1
Department of Neurology, Baoji Municipal Central Hospital, 8 Jiangtan Road, Baoji 721008, Shaanxi, People’s Republic of China
Introduction Cerebral infarction is a common cerebrovascular disease, and it is caused by ischemic necrosis of brain tissue due to insufficient cerebral blood supply. Cerebral infarction has a high incidence in middle-aged and elderly people. With increasing global aging and improved living standards, the incidence of cerebral infarction shows a gradual upward trend. Cerebral infarction due to atherosclerosis is the most common pathological type. Atherosclerosis latter and the resulting inflammatory response to the infarction are two of the main causes of acute ischemic stroke and the continuous compromise of vascular endothelial function, respectively [1–3]. Procalcitonin (PCT) increases in cases of infection, burn, trauma,
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