• PDF / 141,542 Bytes
• 1 Pages / 623.591 x 841.847 pts Page_size
• 88 Downloads / 153 Views

DOWNLOAD

REPORT

---

1

Corticosteroids/penicillins Allergy to carmellose and polysorbate 80 excipients: 2 case reports One patient developed an allergy to penicillins containing polysorbate 80 as an excipient and another patient developed an allergy to corticosteroids containing carmellose as an excipient. A 50-year-old woman had experienced generalised urticaria with angioedema after receiving parenteral penicillin 31 years before admission [therapeutic indication, dosage, treatment duration and outcome not stated] and, about 8 years before admission, her antibody levels to penicilloyl G and V were 0.40 kUA/L and 0.56 kUA/L, respectively. On admission for allergy testing, she had no detectable antibodies to penicillins. She had negative reactions to intradermal tests with penicillins, but positive reactions to penicilloyl-polylysine and the minor determinant mixture (benzylpenicillin and benzylpenicilloate), and to the solvent of these preparations. She had a highly positive reaction to an intradermal test with polysorbate 80 at a concentration of 0.05 mg/mL, an emulsifying agent in the solvent. An oral provocation test with phenoxymethylpenicillin 3.25 mega units, containing no polysorbate 80, was well tolerated. A 50-year-old woman had a history of receiving intraarticular triamcinolone [Volon A] for post-traumatic degenerative rheumatic disorders in her left ankle [dosage and treatment duration not stated], and developing generalised pruritus, urticarial skin eruptions and tension in her head 30 minutes later [patient outcome not stated]. She subsequently underwent allergy testing and had highly positive reactions to SC Volon A and intradermal pure carmellose 0.75 mg/mL. Grims RH, et al. Pitfalls in drug allergy skin testing: false-positive reactions due to (hidden) additives. Contact Dermatitis 54: 290-294, No. 5, May 2006 801067036 Austria

0114-9954/10/1109-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

Reactions 8 Jul 2006 No. 1109