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Posterior encephalopathy reversible syndrome secondary to hypercalcaemia due to hypervitaminosis-D: case report A 29-year-old woman developed posterior encephalopathy reversible syndrome (PRES) secondary to hypercalcaemia due to hypervitaminosis-D while receiving vitamin-D supplementation. Additionally, she was receiving unspecified corticosteroid, which also contributed to the development of PRES [not all dosages and routes stated]. The woman, who had dermatomyositis, had been receiving unspecified oral corticosteroid and vitamin-D supplementation 15 0000 IU/day. At presentation, she had reduced proximal strength, and experienced three episodes of generalised tonic-clonic seizures. She was hospitalised, and due to low level of consciousness, she needed orotracheal intubation. Proximal musculature weakness was observed during neurological examination. MRI demonstrated a diffusely white T2/FLAIR hypersignal predominant in the posterior regions of both the cerebral hemispheres, which was indicative of PRES. Laboratory tests revealed serum calcium level of 15.22 mg/dL (hypercalcaemia). The woman was treated with hydration and forced diuresis, following which her serum calcium normalised with complete resolution of symptoms. Hypercalcaemia due to hypervitaminosis-D and unspecified corticosteroid treatment were considered to be the causes of PRES [time to reactions onsets not stated]. Bernardes L, et al. Posterior Encephalopathy Reversible Syndrome secondary to hypercalcemia due to hypervitaminosis D. European Journal of Neurology 27 (Suppl. 1): 726 803498547 abstr. EPO1322, May 2020 [abstract]

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Reactions 29 Aug 2020 No. 1819