Cost-effectiveness of rapid diagnostic tests, compared to microscopic tests, for the diagnosis and treatment of gestatio
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laria Journal Open Access
RESEARCH
Cost‑effectiveness of rapid diagnostic tests, compared to microscopic tests, for the diagnosis and treatment of gestational malaria in Colombia from an institutional perspective Deisy Cristina Restrepo‑Posada1, Jaime Carmona‑Fonseca2 and Jaiberth Antonio Cardona‑Arias3*
Abstract Background: Gestational malaria is associated with negative outcomes in maternal and gestational health; timely diagnosis is crucial to avoid complications. However, the limited infrastructure, equipment, test reagents, and trained staff make it difficult to use thick blood smear tests in rural areas, where rapid testing could be a viable alternative. The purpose of this study was to estimate the cost-effectiveness of rapid tests type III (Plasmodium falciparum/Plasmodium spp P.f/pan) versus microscopic tests for the diagnosis and treatment of gestational malaria in Colombia. Methods: Cost-effectiveness analyses of gestational malaria diagnosis from an institutional perspective using a decision tree. Standard costing was performed for the identification, measurement and assessment phases, with data from Colombian tariff manuals. The data was collected from Health Situation Analysis, SIVIGILA and meta-analysis. Average and incremental cost-effectiveness ratio were estimated. The uncertainty was assessed through probabilistic sensitivity analysis. Results: The cost of rapid diagnostic tests in 3,000 pregnant women with malaria was US$66,936 and 1,182 disability adjusted life years (DALYs) were estimated. The cost using thick blood smear tests was US$50,838 and 1,023 DALYs, for an incremental cost-effectiveness of US$ 101.2. The probabilistic sensitivity analysis of rapid diagnostic tests deter‑ mined that they are highly cost-effective in 70% of the cases, even below the US$1,200 threshold; also, they showed an incremental net monetary benefit of $150,000 when payer’s willingness is US$1,000. Conclusion: The use of rapid diagnostic tests for timely diagnosis and treatment of gestational malaria is a highly cost-effective strategy in Colombia, with uncertainty analyses supporting the robustness of this conclusion and the increased net monetary benefit that the health system would obtain. This strategy may help in preventing the nega‑ tive effects on maternal health and the neonate at a low cost. Keywords: Cost-effectiveness assessment, Gestational malaria, Rapid diagnostic tests, Thick blood smear tests, Microscopic tests, Colombia
*Correspondence: [email protected] 3 School of Microbiology, University of Antioquia, Calle 70 Number 52–51, Block 5, office 103, Medellin, Colombia Full list of author information is available at the end of the article
Background Malaria is a public health problem worldwide. In 2018, the World Health Organization (WHO) reported 228 million cases of the disease, more than 400,000 deaths, and Africa as the most affected region. In America, 21 countries are endemic with Brazil, Colombia, Guyana,
© The Author(s) 2020. This article is licensed under a Creative Com
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