Cough: Setting the Scene
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Volume 187
Editor-in-Chief F. Hofmann, München Editorial Board J. Beavo, Seattle, WA A. Busch, Berlin D. Ganten, Berlin J.-A. Karlsson, Singapore M. Michel, Amsterdam C.P. Page, London W. Rosenthal, Berlin
Kian Fan Chung
•
John Widdicombe
Editors
Pharmacology and Therapeutics of Cough Contributors M.G. Belvisi, F. Bertram, S.S. Birring, D.C. Bolser, A.C. Bonham, J. Bric, B.J. Canning, M.J. Carr, C.-Y. Chen, Y.-L. Chou, K.F. Chung, P.W. Davenport, P.V. Dicpinigaitis, R. Eccles, E. Ernst, R. Gatti, P. Geppetti, Q. Gu, D.J. Hele, J.P. Joad, L.-Y. Lee, S. Materazzi, S.B. Mazzone, M.A. McAlexander, I.M. McFadzean, L. McGarvey, A.H. Morice, R. Nassini, C.P. Page, D.I. Pavord, A.A. Raj, T. Shirasaki, F. Soeda, D. Spina, K. Takahama, M. Trevisani, B.J. Undem, J.G. Widdicombe
ABC
Prof. Dr. John Widdicombe University of London 116 Pepys Road London SW20 8NY UK [email protected]
Prof. Kian Fan Chung National Heart & Lung Institute Imperial College Dovehouse Street London SW3 6LY UK [email protected]
ISBN 978-3-540-79841-5
e-ISBN 978-3-540-79842-2
Handbook of Experimental Pharmacology ISSN 0171-2004 Library of Congress Control Number: 2008929590 c 2009 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved,
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Preface
The last decade or so has seen remarkable advances in our knowledge of cough. This applies especially to its basic mechanisms: the types of airway sensors, the pharmacological receptors on their membranes, the brainstem organization of the ‘cough centre’, and the involvement of the cerebral cortex in the sensations and the voluntary control of cough. With the exception of the last of these, nearly all the studies have been on experimental animals rather than humans, for obvious reasons. One group of experimental studies has particular relevance to human patients, and that is the demonstration of the sensitization of cough pathways both in the per
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