Could there be a role of serum zonulin increase in the development of hypercalcemia in primary hyperparathyroidism
- PDF / 434,916 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 13 Downloads / 175 Views
ORIGINAL ARTICLE
Could there be a role of serum zonulin increase in the development of hypercalcemia in primary hyperparathyroidism Hakan Korkmaz
1
●
Fevziye Burcu Sirin2 Bora Torus3 ●
1234567890();,:
1234567890();,:
Received: 3 June 2020 / Accepted: 17 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Purpose To evaluate the serum level of zonulin, which is an intestinal permeability (IP) biomarker, in primary hyperparathyroidism (PHPT) and to investigate the relationship between zonulin, calcium, and parathormone (PTH) levels. Methods The study included 34 healthy control (HC) and 39 patients with PHPT. Serum calcium, phosphorus, magnesium, creatinine, albumin, and 24 h urine calcium levels were measured in all groups. Serum levels of zonulin were measured quantitatively by enzyme-linked immunosorbent assay (ELISA). Urinary ultrasonography (to assess the presence of nephrolithiasis) and dual energy X-ray absorptiometry (to assess the presence of osteoporosis) were used to evaluate complications related to PTHP. Results Serum zonulin levels were significantly higher in the PHPT group than the HC group (p < 0.001). Zonulin levels were significantly positively correlated with plasma PTH and serum calcium levels (r = 0.600, p < 0.001 and r = 0.610, p < 0.001; respectively). There was no correlation between serum zonulin levels and adenoma volume. Conclusion Serum zonulin level increases in patients with PHPT. Serum zonulin levels show a moderate/strong positive correlation with serum calcium and plasma PTH levels. This suggests that IP increase may play a role in the development of hypercalcemia in patients with PHPT. Keywords Hypercalcemia Intestinal permeability Primary hyperparathyroidism Zonulin ●
●
Introduction Primary hyperparathyroidism (PHPT) is an endocrine disease characterized by an increase in serum calcium levels together with parathormone (PTH). Approximately 80% of the time, disease is caused by a single parathyroid adenoma [1]. Mechanisms of hypercalcemia in PHPT are increased calcium release from bone to blood, and increased calcium absorption from renal distal tubules and intestines. The role
* Hakan Korkmaz [email protected] 1
Department of Internal Medicine, Division of Endocrinology, Faculty of Medicine, Suleyman Demirel University, Cunur, 32260 Isparta, Turkey
2
Department of Biochemistry, Faculty of Medicine, Suleyman Demirel University, Cunur, 32260 Isparta, Turkey
3
Department of Internal Medicine, Faculty of Medicine, Suleyman Demirel University, Cunur, 32260 Isparta, Turkey
●
of PTH in the regulation of renal epithelial calcium transport is well known, but there are uncertainties about the effect of PTH on intestinal calcium transport. The generally accepted view is that PTH increases the production of 1,25dihydroxyvitamin D3 [1,25(OH)2D3] and indirectly leads to an increase in intestinal calcium absorption through 1,25 (OH)2D3 [2–4]. However, the detection of PTH-related peptide receptor type 1 (PTHR1) in rat duodenal enteroc
Data Loading...
